Braeuer et al., Semin Cancer Biol 2011
(Melanoma...) :
AP-2a regulates the expression of c-KIT, MMP-2, VEGF, and the adhesion molecule MCAM/MUC18 Bar-Eli et al., J Cell Physiol 1997
(Disease Progression...) :
The expression of c-KIT and other genes associated with malignant melanoma ( such as MCAM/MUC18 ) is highly regulated by the transcription factor AP-2 Jean et al., J Biol Chem 1998
(Melanoma...) :
These results indicate that the expression of MCAM/MUC18 is regulated by AP-2 and that enforced AP-2 expression suppresses tumorigenicity and metastatic potential of human melanoma cells, possibly by down regulating MCAM/MUC18 gene expression