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EGF — GAB2
Text-mined interactions from Literome
Kong et al., Mol Endocrinol 2003
:
More recently, we found that
EGF dependent tyrosine phosphorylation of endogenous
Gab2 is essential for EGF induced DNA synthesis in rat hepatocytes ... Western blotting of subcellular fractions from intact liver and immunofluorescence analyses in cultured hepatocytes demonstrated that
EGF did not
promote the association of cytosolic
Gab2 with cell membranes ... Overexpression of the PH domain of Gab2 did not affect
EGF induced
Gab2 phosphorylation, PI3K activation, and DNA synthesis
Meng et al., Biochem J 2005
(MAP Kinase Signaling System) :
Participation of both Gab1 and
Gab2 in the activation of the ERK/MAPK pathway by
epidermal growth factor