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CTNNB1 — LRP5

Pathways - manually collected, often from reviews:

• NCI Pathway Database N-cadherin signaling events: LRP5 (LRP5) → N-cadherin/p120 catenin/beta catenin/alpha catenin complex (CDH2-CTNND1-CTNNB1-CTNNA1) (modification, collaborate)
  Haÿ et al., Mol Cell Biol 2009
  Evidence: physical interaction, other species
• NCI Pathway Database N-cadherin signaling events: LRP5 (LRP5) → N-cadherin/p120 catenin/beta catenin/alpha catenin/LRP5/Axin1 complex (CDH2-CTNNB1-CTNNA1-LRP5-AXIN1-CTNND1) (modification, collaborate)
  Haÿ et al., Mol Cell Biol 2009
  Evidence: physical interaction, other species
• NCI Pathway Database N-cadherin signaling events: Axin1 (AXIN1) → N-cadherin/p120 catenin/beta catenin/alpha catenin/LRP5/Axin1 complex (CDH2-CTNNB1-CTNNA1-LRP5-AXIN1-CTNND1) (modification, collaborate)
  Haÿ et al., Mol Cell Biol 2009
  Evidence: physical interaction, other species
• NCI Pathway Database N-cadherin signaling events: N-cadherin/p120 catenin/beta catenin/alpha catenin complex (CDH2-CTNND1-CTNNB1-CTNNA1) → N-cadherin/p120 catenin/beta catenin/alpha catenin/LRP5/Axin1 complex (CDH2-CTNNB1-CTNNA1-LRP5-AXIN1-CTNND1) (modification, collaborate)
  Haÿ et al., Mol Cell Biol 2009
  Evidence: physical interaction, other species

Text-mined interactions from Literome

Cong et al., Development 2004 : In addition, the beta-catenin signaling mediated by ectopic expression of LRP is not dependent on Disheveled or Wnt, but can also be augmented by oligomerization of LRP receptors
Hay et al., J Biol Chem 2005 : We demonstrate here that LRP5/Frat1 interaction is involved in beta-catenin nuclear translocation and TCF-1 transcriptional activation
Mukhopadhyay et al., Development 2006 : The Dkk family of secreted cysteine-rich proteins regulates Wnt/beta-catenin signaling by interacting with the Wnt co-receptor Lrp5/6
Guo et al., Bone 2007 : Expression of LRP5DeltaN-V , which carries the allele p.1525V, induced higher beta-catenin/TCF-LEF activity compared to LRP5DeltaN-A, which carries the allele p.1525A
Bhat et al., Gene 2007 : In the presence of Wnt1, LRP5 or the HBM variant ( LRP5-G171V ) induces beta-catenin nuclear translocation and activates T cell factor ( TCF ) -luciferase reporter activity
Lindvall et al., Stem Cell Rev 2007 (Breast Neoplasms...) : Furthermore, there is strong evidence suggesting that aberrant activation of Wnt signaling induces mammary tumors from stem/progenitor cells, and that Wnt exerts its oncogenic effects through LRP5/6 mediated activation of beta-catenin and mTOR pathways
Chen et al., J Biol Chem 2007 (Choroidal Neovascularization...) : Down-regulation of VLDLR by small interference RNA resulted in up-regulation of LRP5/6 expression and activation of beta-catenin in cultured endothelial cells
Haÿ et al., Mol Cell Biol 2009 : These data indicate that a previously unrecognized N-cadherin-axin-LRP5 interaction negatively regulates Wnt/beta-catenin signaling and is critical in the regulation of osteoblast function, bone formation, and bone mass
Björklund et al., PloS one 2009 (Breast Neoplasms...) : An aberrantly spliced internally truncated LRP5 receptor ( LRP5Delta666-809, LRP5Delta ) was shown recently to be resistant to DKK1 inhibition, and was required for beta-catenin accumulation in hyperparathyroid tumors and parathyroid tumor growth ... LRP5Delta was required in MCF7 breast cancer cells for the non phosphorylated active beta-catenin level, transcription activity of beta-catenin, cell growth in vitro, and breast tumor growth in a xenograft SCID mouse model
Sunters et al., J Biol Chem 2010 : Mechano-transduction in osteoblastic cells involves strain regulated estrogen receptor alpha mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT dependent Wnt/LRP5 receptor independent activation of beta-catenin signaling
Lu et al., Biochemistry 2010 : Mesd not only blocks binding of Wnt antagonists Dkk1 and Sclerostin to LRP5 and LRP6 but also inhibits Wnt3A and Rspondin1 induced Wnt/beta-catenin signaling in LRP5- and LRP6 expressing cells