◀ Back to RAC1

ICMT — RAC1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: ICMT — RAC1 (in vivo) Ahmad et al., Arterioscler Thromb Vasc Biol 2002*
• IRef Ophid Interaction: RAC1 — ICMT (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Papaharalambus et al., J Biol Chem 2005 : Here, we have shown that ICMT regulates TNF alpha stimulation of Rac1 activity ... To understand the mechanism of inhibition of Rac1 activity, we examined the effect of ICMT inhibition on the interaction of Rac1 with its inhibitor, Rho guanine nucleotide dissociation inhibitor ( RhoGDI ) ... These results suggest that ICMT regulates Rac1 activity by controlling the interaction of Rac1 with RhoGDI ... We hypothesize that ICMT regulates the release of Rac1 from RhoGDI
Jayaram et al., Islets 2011 : Together, these data suggest that ICMT regulates glucose induced Rac1 activation, generation of reactive oxygen species and insulin secretion in pancreatic ß-cells