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IL1B — NOX4

Text-mined interactions from Literome

Bonizzi et al., Mol Cell Biol 1999 (Adenocarcinoma) : Reactive oxygen intermediate dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity
Katsuyama et al., Endocrinology 1999 : Both interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha potently stimulated nitrite/nitrate ( NOx ) production with a concomitant expression of iNOS mRNA and protein as demonstrated by Northern and Western blot analysis, respectively
Isenović et al., Hypertension 2000 : For this, we measured IL-1beta stimulated nitrite ( NOx ) production with use of the Griess reagent, prostaglandin E ( 2 ) ( PGE ( 2 ) ) production with use of an enzyme immunoassay, and arachidonic acid release in the presence and absence of BEL ... BEL inhibited IL-1beta stimulated NOx production and iNOS protein by 88 % and 93 %, respectively
Wu et al., J Neurosci 2002 (Disease Models, Animal...) : In addition, we show that minocycline not only prevents MPTP induced activation of microglia but also the formation of mature interleukin-1beta and the activation of NADPH-oxidase and inducible nitric oxide synthase (iNOS), three key microglial derived cytotoxic mediators
Kaur et al., Med Princ Pract 2004 : Therefore, the main objective of this study was to evaluate the effect of IL-1beta or NO on enzyme activity of NADPH oxidase ( NOX ) , a superoxide generating system recently documented to participate in a variety of vascular functions ... Both IL-1beta and SNP enhanced NOX activity, by 67 and 45 %, respectively, following 24 h of treatment
Shin et al., Circulation 2004 (Arteriosclerosis) : Cilostazol ( 1 to 100 micromol/L ) significantly suppressed not only NAD ( P ) H oxidase dependent superoxide production but also TNF-alpha and interleukin-1beta release and restored viability
Min et al., Glia 2004 (Encephalitis) : Expression of IL-1beta , TNF-alpha, and iNOS in ganglioside treated cells was significantly reduced in the presence of inhibitors of PKC ( GF109203X, Go6976, Ro31-8220, and rottlerin ) and NADPH oxidase ( diphenyleneiodonium chloride [ DPI ] )
Ellmark et al., Cardiovasc Res 2005 : Interleukin-1beta (IL-beta) thrombin and platelet derived growth factor ( PDGF ) also reduced Nox4 mRNA expression after 3 h without affecting Nox1 levels
Tojo et al., J Hypertens 2005 (Hypertension, Renal) : Nicotinamide adenine dinucleotide phosphate ( NAD ( P ) H ) oxidase is regulated by angiotensin II, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha via p38 mitogen activated protein kinase ( MAPK )
Yasuhara et al., Biochem J 2005 : IL-1beta augmented the expression of the catalytic gp91 subunit of NADPH oxidase , gp91phox, as well as inducible NO synthase in ATDC5 cells
Ishizuka et al., Neurosci Res 2008 : Perfusion of Mn ( III ) tetrakis ( 4-benzoic acid ) porphyrin chloride, a superoxide ( O ( 2 ) ( - ) ) dismutase mimic, into the mPFC reduced the increases in levels of 2,3-DHBA induced by centrally administered IL-1beta, but enhanced the increases in levels of NOx ( - ) induced by centrally administered IL-1beta
Ohta et al., J Endocrinol 1993 : Interleukin-1 beta (IL-1 beta) stimulated production of NO2-/NO3- ( NOx ) in a time dependent manner and both NOx and cyclic GMP formation were stimulated in a dose dependent manner by IL-1 beta ... IL-1 beta induced NOx production and intracellular cyclic GMP formation were similarly blocked by an NO synthase inhibitor, NG-monomethyl-L-arginine ( LNMMA ), whose effect was reversed by L-arginine, but not by D-arginine ... Dexamethasone inhibited IL-1 beta induced NOx production in a dose dependent manner ... A calmodulin inhibitor ( W-7 ) showed no effect on IL-1 beta induced NOx production, whereas cycloheximide and the actinomycin D completely inhibited NOx production
Tsujino et al., Circulation 1994 : We studied the effect of human recombinant interleukin-1 beta (IL-1 beta) on synthesis of NO2-/NO3- ( NOx ) and the expression of NOS mRNA and protein in cultured neonatal rat cardiocytes ... IL-1 beta dose-dependently ( 0.1 to 10 ng/mL ) stimulated NOx production as a function of time ( 6 to 48 hours ) ... NG-mono-methyl-L-arginine, an NOS inhibitor, completely blocked the IL-1 beta induced NOx production, whose effect was reversed by L-arginine but not by D-arginine ... Dexamethasone inhibited the IL-1 beta induced NOx production as well as iNOS mRNA expression ... Cycloheximide and actinomycin D completely inhibited the IL-1 beta induced NOx production and iNOS mRNA expression ... Neither a calmodulin inhibitor ( W-7 ), a protein kinase C inhibitor ( calphostin C ), nor a Ca2+ channel antagonist ( nicardipine ) showed any effect on the IL-1 beta induced NOx production
Kanno et al., Am J Physiol 1994 : Among several cytokines and bacterial lipopolysaccharide tested, IL-1 beta most effectively stimulated NOx production ... Northern blot analysis using cDNA for mouse liver iNOS as a probe showed that IL-1 beta induced expression of iNOS mRNA and stimulated NOx production in a dose- and time dependent manner ... Transforming growth factor ( TGF ) -beta and dexamethasone blocked the IL-1 beta induced NOx production as well as expression of iNOS mRNA and protein ... TGF-beta dose dependently inhibited the IL-1 beta induced NOx production and iNOS mRNA expression