◀ Back to HDAC1
E2F1 — HDAC1
Pathways - manually collected, often from reviews:
-
BioCarta cell cycle: g1/s check point:
RB/HDAC/ABL/E2F-1/DP-1 complex (E2F1-RB1-TFDP1-ABL1-HDAC1)
→
Cyclin E/CDK2 complex (CCNE1-CDK2)
(modification, collaborate)
-
BioCarta cell cycle: g1/s check point:
RB/HDAC/ABL/E2F-1/DP-1 complex (E2F1-RB1-TFDP1-ABL1-HDAC1)
→
E2F-1/DP-1 complex (TFDP1-E2F1)
(modification, collaborate)
-
BioCarta cell cycle: g1/s check point:
RB/HDAC/ABL/E2F-1/DP-1 complex (E2F1-RB1-TFDP1-ABL1-HDAC1)
→
CYCLIN D1/CDK4/CDK6 complex (CCND1-CDK4-CDK6)
(modification, collaborate)
-
BioCarta cell cycle: g1/s check point:
RB/HDAC/ABL/E2F-1/DP-1 complex (E2F1-RB1-TFDP1-ABL1-HDAC1)
→
E2F-1/DP-1 complex (TFDP1-E2F1)
(modification, collaborate)
-
NCI Pathway Database E2F transcription factor network:
E2F1/DP complex (E2F1-TFDP2_TFDP1)
→
E2F4/DP2/p107-p130/HDAC1 complex (E2F4-RBL2_RBL1-TFDP2-HDAC1)
(transcription, activates)
Takahashi et al., Genes Dev 2000, Johnson et al., Genes Dev 1994, Hsiao et al., Genes Dev 1994, Hurford et al., Genes Dev 1997, Ferreira et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database E2F transcription factor network:
E2F4/DP2/p107-p130/HDAC1 complex (E2F4-RBL2_RBL1-TFDP2-HDAC1)
→
E2F1 (E2F1)
(transcription, inhibits)
Takahashi et al., Genes Dev 2000, Johnson et al., Genes Dev 1994, Hsiao et al., Genes Dev 1994, Hurford et al., Genes Dev 1997, Ferreira et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/CHE-1 complex (RB1-AATF-E2F3_E2F2_E2F1-TFDP1)
→
HDAC1 (HDAC1)
(modification, collaborate)
Fanciulli et al., FASEB J 2000, Bruno et al., Cancer Cell 2002, Brehm et al., Nature 1998, Magnaghi-Jaulin et al., Nature 1998, Luo et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/CHE-1 complex (RB1-AATF-E2F3_E2F2_E2F1-TFDP1)
→
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Fanciulli et al., FASEB J 2000, Bruno et al., Cancer Cell 2002, Brehm et al., Nature 1998, Magnaghi-Jaulin et al., Nature 1998, Luo et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
HDAC1 (HDAC1)
→
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Fanciulli et al., FASEB J 2000, Bruno et al., Cancer Cell 2002, Brehm et al., Nature 1998, Magnaghi-Jaulin et al., Nature 1998, Luo et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
HDAC1 (HDAC1)
→
RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Fanciulli et al., FASEB J 2000, Bruno et al., Cancer Cell 2002, Brehm et al., Nature 1998, Magnaghi-Jaulin et al., Nature 1998, Luo et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
CHE-1 (AATF)
→
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Fanciulli et al., FASEB J 2000, Bruno et al., Cancer Cell 2002, Brehm et al., Nature 1998, Magnaghi-Jaulin et al., Nature 1998, Luo et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
→
RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Fanciulli et al., FASEB J 2000, Bruno et al., Cancer Cell 2002, Brehm et al., Nature 1998, Magnaghi-Jaulin et al., Nature 1998, Luo et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
DNMT1 (DNMT1)
→
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Robertson et al., Nat Genet 2000
Evidence: physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
DNMT1 (DNMT1)
→
RB1/E2F1-3/DP/HDAC1/DNMT1 complex (RB1-HDAC1-DNMT1-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Robertson et al., Nat Genet 2000
Evidence: physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
→
RB1/E2F1-3/DP/HDAC1/DNMT1 complex (RB1-HDAC1-DNMT1-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Robertson et al., Nat Genet 2000
Evidence: physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1)
→
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1)
→
HDAC1 (HDAC1)
(modification, collaborate)
Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
→
CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A)
(modification, collaborate)
Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
→
HDAC1 (HDAC1)
(modification, collaborate)
Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
→
CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1)
(modification, collaborate)
Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RBBP4 (RBBP4)
→
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Nicolas et al., Nucleic Acids Res 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RBBP4 (RBBP4)
→
RB1/E2F1-3/DP/HDAC1/RBBP4 complex (RB1-HDAC1-RBBP4-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Nicolas et al., Nucleic Acids Res 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
→
RB1/E2F1-3/DP/HDAC1/RBBP4 complex (RB1-HDAC1-RBBP4-E2F3_E2F2_E2F1-TFDP1)
(modification, collaborate)
Nicolas et al., Nucleic Acids Res 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database E2F transcription factor network:
E2F1/DP complex (E2F1-TFDP2_TFDP1)
→
HDAC1 (HDAC1)
(modification, collaborate)
Wang et al., J Biol Chem 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database E2F transcription factor network:
E2F1/DP complex (E2F1-TFDP2_TFDP1)
→
E2F1/DP/HDAC1 complex (E2F1-TFDP2_TFDP1-HDAC1)
(modification, collaborate)
Wang et al., J Biol Chem 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database E2F transcription factor network:
HDAC1 (HDAC1)
→
E2F1/DP/HDAC1 complex (E2F1-TFDP2_TFDP1-HDAC1)
(modification, collaborate)
Wang et al., J Biol Chem 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database E2F transcription factor network:
KAP1 (TRIM28)
→
E2F1/DP/HDAC1 complex (E2F1-TFDP2_TFDP1-HDAC1)
(modification, activates)
Wang et al., J Biol Chem 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database E2F transcription factor network:
PRMT5 (PRMT5)
→
RB1/E2F1-3/DP/HDAC1/RBBP4 complex (RB1-HDAC1-RBBP4-E2F3_E2F2_E2F1-TFDP1)
(transcription, inhibits)
Fabbrizio et al., EMBO Rep 2002, Ohtani et al., Proc Natl Acad Sci U S A 1995, Hurford et al., Genes Dev 1997
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database E2F transcription factor network:
E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1)
→
RB1/E2F1-3/DP/HDAC1/RBBP4 complex (RB1-HDAC1-RBBP4-E2F3_E2F2_E2F1-TFDP1)
(transcription, activates)
Fabbrizio et al., EMBO Rep 2002, Ohtani et al., Proc Natl Acad Sci U S A 1995, Hurford et al., Genes Dev 1997
Evidence: mutant phenotype, reporter gene, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
HDAC1
—
E2F1
(physical association, affinity chromatography technology)
Nicolas et al., J Biol Chem 2000*
-
IRef Biogrid Interaction:
HDAC1
—
E2F1
(physical association, affinity chromatography technology)
Zhou et al., Biochem Biophys Res Commun 2008*
-
MIPS CORUM DNMT1-RB1-HDAC1-E2F1 complex:
DNMT1-RB1-HDAC1-E2F1 complex complex (DNMT1-E2F1-HDAC1-RB1)
Robertson et al., Nat Genet 2000
-
IRef Corum Interaction:
Complex of RB1-HDAC1-DNMT1-E2F1
(association, cosedimentation)
Robertson et al., Nat Genet 2000
-
IRef Dip Interaction:
HDAC1
—
E2F1
(physical association, coimmunoprecipitation)
Brehm et al., Nature 1998
-
IRef Dip Interaction:
HDAC1
—
E2F1
(physical association, affinity chromatography technology)
Brehm et al., Nature 1998
-
IRef Dip Interaction:
HDAC1
—
E2F1
(physical association, affinity chromatography technology)
Magnaghi-Jaulin et al., Nature 1998
-
IRef Hprd Interaction:
Complex of HDAC1-E2F1-DNMT1-HDAC1-E2F1-DNMT1-DNMT1-HDAC1-E2F1
(in vivo)
Robertson et al., Nat Genet 2000
-
IRef Ophid Interaction:
HDAC1
—
E2F1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
HDAC1
—
E2F1
(aggregation, confirmational text mining)
Robertson et al., Nat Genet 2000
Text-mined interactions from Literome
Nicolas et al., J Biol Chem 2000
(Retinoblastoma) :
Finally, we found that
E2F1 and RbAp48 are physically associated in the
presence of Rb and
HDAC1 , suggesting that RbAp48 could be involved in transcriptional repression of E2F-responsive genes
Boutillier et al., J Neurochem 2003
:
Taken together, our results suggest that, in neuroprotective conditions,
histone deacetylase activity
allows a constitutive repression of the
e2f-1 gene in mature neurones in order to ensure survival
Joshi et al., Biochem Biophys Res Commun 2003
(Breast Neoplasms) :
Like full-length prohibitin, the coiled-coil domain also recruited
histone deacetylase 1 to
repress E2F1
Hlaing et al., J Biol Chem 2004
(Hypertrophy) :
We demonstrated previously that angiotensin II stimulates hypertrophy in C2C12 myoblasts by transient activation of the cyclin dependent kinase 4 complex, subsequent phosphorylation of retinoblastoma protein, release of
histone deacetylase 1 from the retinoblastoma protein inhibitory complex, and partial
activation of the transcription factor
E2F-1
Zhang et al., Nucleic Acids Res 2005
:
The ErbB3 binding protein Ebp1 interacts with
Sin3A to
repress E2F1 and AR-mediated transcription ... Functionally,
Sin3A enhanced the ability of Ebp1 to repress transcription of androgen receptor (AR) and
E2F1 regulated genes
Duan et al., Prostate 2013
(Prostatic Neoplasms) :
While androgen suppresses EZH2 in CRPC cells, in LNCaP cells, physiological concentrations of androgen stimulate expression of
PRC2 genes ( EZH2, SUZ12, and EED ), which is mediated by androgen induced ANCCA and
involves E2F and histone H3K4me3 methylase MLL1 complex