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FOXO4 — IGF1
Text-mined interactions from Literome
Hansen et al., PLoS Genet 2008
:
Long lived daf-2
insulin/IGF-1 receptor mutants
require both autophagy and the transcription factor
DAF-16/FOXO for their longevity, but we find that autophagy takes place in the absence of DAF-16
Essaghir et al., J Biol Chem 2009
:
PDGF, fibroblast growth factors ( FGF ), and
IGF-I repressed the expression of
FOXO genes in human fibroblasts
Cleveland et al., Am J Physiol Regul Integr Comp Physiol 2010
:
IGF-I and insulin
stimulated phosphorylation of FOXO1 and
FOXO4 ( P < 0.05 ), which was inhibited by the phosphatidylinositol 3-kinase ( PI 3-kinase ) inhibitor wortmannin, and decreased the abundance of polyubiquitinated proteins by 10-20 % ( P < 0.05 )
Kenyon et al., Ann N Y Acad Sci 2010
:
However, the mechanisms by which inhibition of
insulin/IGF-1 signaling and germline loss
activate DAF-16/FOXO are distinct
Löw et al., Gen Comp Endocrinol 2011
(Nerve Degeneration) :
Longevity increases when
FoxO becomes activated in
response to reduced
insulin/IGF-1 signalling