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CDH1 — MMP3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Mei et al., Carcinogenesis 2002
:
The sum effect of MMP inhibitors demonstrated that NO-induced activation of
MMP may
cause the degradation of
E-cadherin and the subsequent dissociation of beta-catenin, thereby contributing to the cytosolic accumulation of beta-catenin and nuclear formation of beta-catenin/LEF-1 complex
Nawrocki-Raby et al., Am J Pathol 2003
(Bronchial Neoplasms...) :
E-Cadherin mediates
MMP down-regulation in highly invasive bronchial tumor cells
Wang et al., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2004
(Lymphatic Metastasis...) :
In the group of nasopharyngeal carcinoma with distant metastasis, the expression of
E-cadherin and nm23H1 also increased and the expression of CD44H,
MMP-3 and VEGF all
increased ... In the group of nasopharyngeal carcinoma with distant metastasis, the expression of
E-cadherin and nm23H1 also increased and the expression of CD44H,
MMP-3 and VEGF all
increased
Zhao et al., Cancer Lett 2013
(Neovascularization, Pathologic...) :
EA also reversed epithelial to mesenchymal transition by up-regulating
E-cadherin and
inhibiting the expression of Snail,
MMP-2 and MMP-9
Lochter et al., J Cell Biol 1997
(Cell Transformation, Neoplastic) :
Induction of
SL-1 expression
resulted in cleavage of
E-cadherin , and triggered progressive phenotypic conversion characterized by disappearance of E-cadherin and catenins from cell-cell contacts, downregulation of cytokeratins, upregulation of vimentin, induction of keratinocyte growth factor expression and activation, and upregulation of endogenous MMPs. Cells expressing SL-1 were unable to undergo lactogenic differentiation and became invasive ... Induction of
SL-1 expression
resulted in cleavage of
E-cadherin , and triggered progressive phenotypic conversion characterized by disappearance of E-cadherin and catenins from cell-cell contacts, downregulation of cytokeratins, upregulation of vimentin, induction of keratinocyte growth factor expression and activation, and upregulation of endogenous MMPs. Cells expressing SL-1 were unable to undergo lactogenic differentiation and became invasive