Gene interactions and pathways from curated databases and text-mining

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IL6 — RHO

Text-mined interactions from Literome

Radeff et al., J Bone Miner Res 2004 : Rho and Rho kinase are involved in parathyroid hormone stimulated protein kinase C alpha translocation and IL-6 promoter activity in osteoblastic cells
Ueno et al., J Biol Chem 2006 (Carcinoma, Renal Cell...) : Furthermore, IL-6 promoted Rho activation, and the effect was potentiated by NEU3, leading to increased cell motility that was again affected by LY294002
Oz-Arslan et al., J Leukoc Biol 2006 : Further analyses show that inhibitors of phosholipase D, Rho , and protein kinase C also inhibited the LPL induced release of IL-6 and IL-8
Ito et al., Spine (Phila Pa 1976) 2007 (Disease Models, Animal...) : Furthermore, it is thought that Rho is involved in TNF-alpha and interleukin ( IL ) production in the central nervous system, and the production was inhibited by administering Rho kinase inhibitor in the central nervous system
Minamitani et al., Mol Cell Endocrinol 2008 : Involvement of Rho-kinase in prostaglandin F2alpha stimulated interleukin-6 synthesis via p38 mitogen activated protein kinase in osteoblasts ... Fasudil, another inhibitor of Rho-kinase , suppressed the PGF ( 2alpha ) -stimulated IL-6 synthesis ... These results strongly suggest that Rho-kinase regulates PGF ( 2alpha ) -stimulated IL-6 synthesis via p38 MAP kinase activation in osteoblasts
Tokuda et al., Prostaglandins Leukot Essent Fatty Acids 2008 : Fasudil, another inhibitor of Rho-kinase , suppressed the PGD2 stimulated IL-6 synthesis ... These results strongly suggest that Rho-kinase regulates PGD2 stimulated IL-6 synthesis via p38 MAP kinase activation in osteoblasts
Kato et al., Int J Mol Med 2011 : Rho-kinase regulates thrombin stimulated interleukin-6 synthesis via p38 mitogen activated protein kinase in osteoblasts ... Fasudil, another inhibitor of Rho-kinase , suppressed thrombin stimulated IL-6 synthesis ... These results strongly suggest that Rho-kinase regulates thrombin stimulated IL-6 synthesis via p38 MAP kinase activation in osteoblasts