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IL6 — RHO
Text-mined interactions from Literome
Radeff et al., J Bone Miner Res 2004
:
Rho and Rho kinase are
involved in parathyroid hormone stimulated protein kinase C alpha translocation and
IL-6 promoter activity in osteoblastic cells
Ueno et al., J Biol Chem 2006
(Carcinoma, Renal Cell...) :
Furthermore,
IL-6 promoted
Rho activation, and the effect was potentiated by NEU3, leading to increased cell motility that was again affected by LY294002
Oz-Arslan et al., J Leukoc Biol 2006
:
Further analyses show that inhibitors of phosholipase D,
Rho , and protein kinase C also
inhibited the LPL induced release of
IL-6 and IL-8
Ito et al., Spine (Phila Pa 1976) 2007
(Disease Models, Animal...) :
Furthermore, it is thought that
Rho is
involved in TNF-alpha and
interleukin ( IL ) production in the central nervous system, and the production was inhibited by administering Rho kinase inhibitor in the central nervous system
Minamitani et al., Mol Cell Endocrinol 2008
:
Involvement of
Rho-kinase in prostaglandin F2alpha stimulated
interleukin-6 synthesis via p38 mitogen activated protein kinase in osteoblasts ... Fasudil, another inhibitor of
Rho-kinase ,
suppressed the PGF ( 2alpha ) -stimulated
IL-6 synthesis ... These results strongly suggest that
Rho-kinase regulates PGF ( 2alpha ) -stimulated
IL-6 synthesis via p38 MAP kinase activation in osteoblasts
Tokuda et al., Prostaglandins Leukot Essent Fatty Acids 2008
:
Fasudil, another inhibitor of
Rho-kinase ,
suppressed the PGD2 stimulated
IL-6 synthesis ... These results strongly suggest that
Rho-kinase regulates PGD2 stimulated
IL-6 synthesis via p38 MAP kinase activation in osteoblasts
Kato et al., Int J Mol Med 2011
:
Rho-kinase regulates thrombin stimulated
interleukin-6 synthesis via p38 mitogen activated protein kinase in osteoblasts ... Fasudil, another inhibitor of
Rho-kinase ,
suppressed thrombin stimulated
IL-6 synthesis ... These results strongly suggest that
Rho-kinase regulates thrombin stimulated
IL-6 synthesis via p38 MAP kinase activation in osteoblasts