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IL2 — PPARA
Text-mined interactions from Literome
Daynes et al., Antioxid Redox Signal 2003
:
Lower
PPARalpha levels are present in aged CD4+ T cells, and appear
responsible for the suppressed
interleukin-2 and exaggerated IFNgamma responses by these cells
Raman et al., Mol Pharmacol 2011
:
2-AG mediated
IL-2 suppression is
dependent on cyclooxygenase-2 (COX-2) metabolism and peroxisome proliferator activated receptor ? (
PPAR? ) activation
Borland et al., Cell Signal 2011
:
However, these studies demonstrate that stable over-expression of PPARß/d or
PPAR? significantly increases the efficacy of ligand activation and
represses UVB induced expression of tumor necrosis factor a (TNFa),
interleukin 6 (IL6), or IL8 in HaCaT keratinocytes, thereby establishing an excellent model to study the functional role of these receptors in human keratinocytes
Martín et al., J Hypertens 2012
:
In addition, pioglitazone increased the
interleukin-1ß induced
PPAR? mRNA levels