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IL2 — TAC3

Text-mined interactions from Literome

Weil-Hillman et al., Cancer Res 1990 : However, this IL-2/p75 interaction induces TAC chain synthesis and formation of high affinity IL-2 receptor required for the proliferation of resting peripheral blood lymphocytes
Tanaka et al., Growth Factors 1990 (Leukemia, Myeloid...) : These findings indicate that IL-2 can mediate the tissue factor induction in the monocytic type of AML and the effect is not mediated by Tac receptors
Yang et al., Cancer Res 1990 (Lung Neoplasms) : Studies of cytokine receptor expression indicated that OKT3 plus IL-2 plus TNF caused an earlier up-regulation of the IL-2 receptor beta chain ( Tac ) and higher TNF receptor expression by day 6 compared to 100 units/ml IL-2 alone
Scholz et al., Cell Signal 1989 (Leukemia) : Synergistic induction of interleukin 2 receptor ( TAC ) expression on YT cells by interleukin 1 or tumor necrosis factor alpha in combination with cAMP inducing agents
Ueda et al., J Immunol 1989 (Lupus Erythematosus, Systemic) : When S. aureus Cowan I-activated normal B cells were separated into Tac-antigen (Tac-Ag)+ and Tac-Ag- cells by employing a rosette technique, IL-2 induced only the Tac-Ag+ cells to proliferate, whereas both the Tac-Ag+ and Tac-Ag- cells responded to BCGF
Tokuda et al., Cancer Immunol Immunother 1989 : Surface marker analyses of Tac antigen and transferrin receptor (TfR) showed that the presence of IFN alpha throughout the culture period significantly suppressed the typical increase in IL-2 induced Tac- and TfR positive cells
Economou et al., Immunology 1989 : IL-2 does, however, induce Tac mRNA and Tac peptide expression on peripheral blood monocytes ( PBM )
Fong et al., Nat Immun Cell Growth Regul 1989 : Increase in Tac mRNA expression in natural killer-like cell line in response to interleukin-1 and interleukin-2 shown at the population and cellular level by in situ hybridization
Farrar et al., J Immunol 1986 : In contrast, IL 2 alone could only increase Tac expression and stimulate PK-C translocation on day 5 but not day 12 activated T cells ... IL 2 synergizes with alpha-T3 and phorbol ester for the regulation of Tac expression ... Although IL 2 increased expression of Tac , the majority if not all of these receptors possessed low affinity for IL 2
Woods et al., Immunol Cell Biol 1987 : Human T lymphocyte colonies require IL2 and are inhibited by anti-Tac
Treiger et al., J Immunol 1986 : The secreted receptor protein ( 44,000 to 46,000 Mr ) retained the capacity to bind both IL 2 and the monoclonal anti-Tac antibody, as evidenced by retention on IL 2 and anti-Tac affinity columns, inhibition of [ 3H ] -anti-Tac binding to HUT 102B2 cells, and partial inhibition of IL 2-induced CTLL proliferation
Tsudo et al., Proc Natl Acad Sci U S A 1987 (Leukemia) : Neither the IL-2 induced proliferation nor the up-regulation of Tac gene expression was inhibited by the addition of anti-Tac
Robb et al., J Exp Med 1984 : That the low-affinity binding, as well as the high-affinity interaction, was associated with the Tac molecule was indicated by the finding that the antibody could substantially or totally block the entire spectrum of IL-2 binding and by the finding that IL-2 could in turn block all radiolabeled anti-Tac binding
Reem et al., Science 1984 : In a population of T lymphocytes prevented from synthesizing IL-2 by dexamethasone and incapable of using IL-2 as a result of blockage of IL-2 receptors by anti-Tac , the number of receptor bearing cells and receptor density were diminished
Bettens et al., J Immunol 1984 : In these studies, IL 2-induced RNA synthesis, and subsequent proliferation of DEX treated and PHA stimulated cells was inhibited by anti-Tac