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IRF6 — MUC5AC

Text-mined interactions from Literome

Zen et al., Am J Pathol 2002 (Liver Diseases) : It was found that LPS up-regulated the expression of MUC2 and MUC5AC in cultured murine biliary epithelial cells ... These findings suggest that LPS can induce overexpression of MUC2 and MUC5AC in biliary epithelial cells via synthesis of TNF-alpha and activation of protein kinase C
Slomiany et al., IUBMB Life 2003 (Helicobacter Infections) : In this study, we report that PPARgamma activation leading to the impedance of H. pylori lipopolysaccharide (LPS) inhibitory effect on gastric mucin synthesis occurs with the involvement of phosphatidylinositol 3-kinase (PI3K) and extracellular signal regulated kinase ( ERK ) pathways
Shao et al., Proc Natl Acad Sci U S A 2003 : PMA, PA sup, and LPS increased MUC5AC gene expression and mucin protein production, effects that were prevented by pretreatment with AG1478, a selective inhibitor of EGFR phosphorylation and by preincubation with an EGFR neutralizing Ab or with a TGF-alpha neutralizing Ab, implicating ligand ( TGF-alpha ) -dependent EGFR phosphorylation in mucin production
Slomiany et al., Inflammopharmacology 2004 : These findings indicate that PPARgamma activation leading to the suppression of H. pylori LPS inhibition of gastric mucin synthesis involves Src kinase dependent EGFR transactivation
Gray et al., Mol Pharmacol 2004 : We also observed that tumor necrosis factor (TNF)-alpha, platelet activating factor (PAF), and lipopolysaccharide (LPS) induced COX-2 and increased MUC5AC production that was blocked by celecoxib, suggesting a common signaling pathway of inflammatory mediator induced MUC5AC production in NHTBE cells ... We conclude that the induction of MUC5AC by IL-1beta, TNF-alpha, PAF, and LPS involves COX-2- generated PGE ( 2 ), activation of EP2 and/or EP4 receptor ( s ), and cAMP-PKA mediated signaling
He et al., Acta Pharmacol Sin 2004 : LPS can induce MUC5AC mucin release from HSBTF and HBEC
Slomiany et al., Scand J Gastroenterol 2005 : The LPS inhibitory effect on gastric mucin synthesis was accompanied by a marked increase in ET-1 generation and enhancement in ECE-1 activity
Griffin et al., Cell Microbiol 2007 : In particular, MUC5AC expression can be induced by cigarette-smoke, neutrophil elastase and lipopolysaccharide (LPS) following activation of tumour necrosis factor alpha converting enzyme
Rhee et al., Eur Respir J 2008 : MUC5AC mucin synthesis and the expression of the MUC5AC gene were increased by LPS in rats or TNF-alpha in NCI-H292 cells ; these effects were inhibited by fudosteine treatment
Antonela Antoniu et al., Expert Opin Investig Drugs 2009 : Both LPS and TNF-alpha increased MUC5AC mucin production in vivo and in vitro, respectively, and fudosteine was found to reduce it by partially interfering with the kinase mediated inflammation pathway that activates the MUC5AC gene
Wang et al., Arch Biochem Biophys 2009 : We explored the role of MMP-9 in LPS induced MUC5AC production and the effect of doxycycline on MUC5AC production ... The study showed that LPS induced transcription and protein expression of both MMP-9 and MUC5AC in NCI-H292 cells and in primary human epithelial cells, and the increased MUC5AC level were associated with increased MMP-9 transcripts, protein and activity ... These results suggested that LPS induced MUC5AC production may be partially mediated by MMP-9 activation and EGFR-p38 MAPK/JNK signaling pathway
Binker et al., Biochem Biophys Res Commun 2009 (Pulmonary Disease, Chronic Obstructive) : LPS stimulated MUC5AC production involves Rac1 dependent MMP-9 secretion and activation in NCI-H292 cells ... Previous studies have reported that lipopolysaccharides (LPS) stimulate mucin 5AC (MUC5AC) production via epidermal growth factor receptor (EGFR) in human airway cells
Gosalia et al., J Biol Chem 2013 : LPS increased the expression of MUC2 and MUC5AC and reduced MUC5B
Yang et al., Ann Hepatol 2013 (Cholelithiasis) : Selective COX-2 inhibitor suppressed LPS induced MUC2 and MUC5AC mRNA expression remarkably
Li et al., PloS one 2013 : Our aim was to clarify whether Duox1 was also involved in the PA-LPS induced MUC5AC and calcium dependent chloride channel 3(Clca3), another recognized marker of goblet cell hyperplasia and mucus hyper production ... Nox inhibitors diphenyleneiodonium chloride ( DPI ) and Duox1 siRNA were used to investigate whether Duox1 is involved in PA-LPS induced MUC5AC and Clca3 expression both in vitro and in vivo ... DPI significantly inhibited PA-LPS induced up-regulation of Duox1, Muc5ac and Clca3 in primary mouse trachea epithelial cells and lung tissues of mice ... Knockdown of Duox1 markedly inhibited PA-LPS induced MUC5AC expression via a ROS-TGF-a cascade in A549 cells ... We demonstrate for the first time that PA-LPS induced MUC5AC and Clca3 expression is partly through Duox1, and provide supportive evidence for Duox1 as a potential target in treatments of mucin over production diseases