Klampfer et al., J Biol Chem 1995
:
Activation of the TSG-6 gene by NF-IL6 requires two adjacent NF-IL6 binding sites ... Moreover, a mutation in the NF-IL6* site abolished transactivation of the TSG-6 promoter by NF-IL6 despite the presence of the intact promoter-distal NF-IL6 site
Klampfer et al., Mol Cell Biol 1994
:
Consistent with this possibility, IL-1 and TNF-alpha markedly increase the binding of Fos and Jun to the AP-1 site, and NF-IL6 activates the native TSG-6 promoter