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FGF21 — GCG

Text-mined interactions from Literome

Kharitonenkov et al., Endocrinology 2007 (Body Weight...) : When administered daily for 6 wk to diabetic rhesus monkeys, FGF-21 caused a dramatic decline in fasting plasma glucose, fructosamine, triglycerides, insulin, and glucagon
Berglund et al., Am J Physiol Endocrinol Metab 2010 : The hypothesis that increases in hepatic glucagon action stimulate AMP activated protein kinase (AMPK) signaling and peroxisome proliferator activated receptor-a ( PPARa ) and fibroblast growth factor 21 (FGF21) expression in a manner modulated by fatty acids was tested in vivo ... These findings demonstrate that glucagon exerts a critical regulatory role in liver to stimulate pathways linked to lipid metabolism in vivo and shows for the first time that effects of glucagon on PPARa and FGF21 expression are amplified by a physiological increase in circulating lipids
Arafat et al., Diabetologia 2013 (Diabetes Mellitus, Experimental...) : Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels : a novel mechanism of glucagon stimulated lipolysis ? ... The effects of exogenous glucagon on plasma FGF-21 levels and lipolysis were evaluated in healthy volunteers and humans with type 1 diabetes, as well as in rodents with streptozotocin (STZ) induced insulinopenic diabetes ... In vitro, the role of glucagon on FGF-21 secretion and lipolysis was studied using isolated primary rat hepatocytes and adipocytes ... In addition, glucagon increased circulating FGF-21 in healthy humans and rodents, as well as in patients with type 1 diabetes, and insulinopenic rodents ... Glucagon stimulated FGF-21 secretion from isolated primary hepatocytes and adipocytes derived from animals with insulinopenic diabetes ... These results indicate that glucagon increases circulating FGF-21 independently of endogenous insulin levels