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GCG — NTS

Pathways - manually collected, often from reviews:

• Reactome Reaction: GCG → NTS (reaction) Rubio et al., Genomics 1999, Dowal et al., J Biol Chem 2006, Amatruda et al., Proc Natl Acad Sci U S A 1991, Ferguson et al., J Biol Chem 1986, Chen et al., Biochim Biophys Acta 1996

Text-mined interactions from Literome

Dolais-Kitabgi et al., Endocrinology 1979 : Effect of neurotensin on insulin, glucagon , and somatostatin release from isolated pancreatic islets ... The effects of neurotensin on the release of insulin, glucagon , and somatostatin were investigated in isolated pancreatic islets prepared from 3- to 4-day-old rats and maintained in culture for 48 h before use ... In 20-min incubations at 3 mM glucose, neurotensin ( 10-100 nM ) increased the release of insulin, glucagon , and somatostatin by 60 %, 90 %, and 110 %, respectively ... It is concluded that neurotensin exerts a dual effect on the endocrine pancreas in vitro : 1 ) at low glucose concentration and over short term ( 20 min ) incubations, the peptide stimulates insulin, glucagon, and somatostatin release ; and 2 ) under stimulated conditions ( high glucose or arginine ), neurotensin inhibits insulin, glucagon , and somatostatin release
Itatsu et al., Endocrinol Jpn 1981 : The histaminergic mechanism of neurotensin induced glucagon release from isolated rat pancreatic islets ... Both histamine ( 100 microM ) and neurotensin ( 100 nM ) stimulated glucagon release from the isolated islets, but not insulin release ... The stimulation of glucagon release occurred in the presence of 10 and 100 nM neurotensin , while the release of insulin was inhibited in the presence of 1 and 10 nM neurotensin ... The neurotensin induced glucagon release was completely inhibited by 1 mM metiamide, an histamine H2-receptor antagonist, added to the incubation medium and not inhibited by 1 mM diphenhydramine, an histamine H1-receptor antagonist ... The results indicate that the histaminergic mechanism, including the H2-receptor system, may be involved in neurotensin induced glucagon release from the endocrine pancreas
Ukai et al., Endocrinology 1977 : Effect of somatostatin on neurotensin induced glucagon release and hyperglycemia ... Infusion of somatostatin along with neurotensin suppressed glucagon and insulin responses to neurotensin and prevented the rise in blood glucose levels
Dumoulin et al., Endocrinology 1998 : Peptide YY, glucagon-like peptide-1, and neurotensin responses to luminal factors in the isolated vascularly perfused rat ileum