Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Lei et al., Amino Acids 2013 : In contrast, cortisol and glucagon increased leucine transamination, leucine oxidative decarboxylation, KIC production, the oxidation of leucine 2-6 carbons and the syntheses of glutamate plus glutamine
Chang et al., Diabetes Care 2013 : RESULTS ID glutamine stimulated glucagon-like peptide 1 ( GLP-1 ; healthy : P < 0.05 ; T2DM : P < 0.05 ), glucose dependent insulinotropic polypeptide ( GIP ; P = 0.098 ; P < 0.05 ), glucagon ( P < 0.01 ; P < 0.001 ), insulin ( P = 0.05 ; P < 0.01 ), and phasic pyloric pressures ( P < 0.05 ; P < 0.05 ), but did not lower blood glucose ( P = 0.077 ; P = 0.5 )
Leclercq-Meyer et al., Endocrinology 1985 : Thus, leucine exerted a dual effect on the secretion of glucagon, the inhibitory effect of leucine prevailing at a high concentration of the branched chain amino acid and when glucagon secretion was already stimulated by arginine or glutamine
Ostenson et al., Acta Endocrinol (Copenh) 1985 : Evidence for metabolic regulation of pancreatic glucagon secretion by L-glutamine ... Furthermore, the regulation of glucagon secretion by glutamine appears to be reciprocally related to factors affecting glucose metabolism and ATP-levels in the A-cell
Bassett et al., J Dev Physiol 1982 : The amino acids glycine, L-serine, L-asparagine and L-glutamine at 5 mmol/l each markedly increased glucagon release from perifused fetal lamb pancreas tissue, whereas the branched-chain amino acids L-leucine and L-valine had no effect
Stumvoll et al., Metabolism 1998 : Glucagon had no effect on the renal net balance, fractional extraction, or uptake and release of either glucose or glutamine