◀ Back to GCG
GCG — TRH
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Benický et al., Eur J Endocrinol 2000
:
Glucagon ( 10 ( -7 ) mol/l ) did not
affect either basal or glucose stimulated release of
TRH , while insulin ( 10 ( -7 ) and 10 ( -6 ) mol/l ) inhibited both
Morley et al., Endocrinology 1979
:
TRH ( 10 ng/ml ) by itself
had no effect on insulin or
glucagon release ...
TRH enhanced arginine induced
glucagon release ; mean summated glucagon was 8228 +/- 1138 ( SE ) pg/ml compared to controls ( 4530 +/- 447 pg/ml ; P less than 0.01 )
Fragner et al., J Endocrinol 2001
:
Endogenous
TRH positively
regulates glucagon secretion and attenuates pancreatic exocrine secretion
Ebiou et al., Endocrinology 1992
:
The data indicate that exogenous
TRH enhances basal
glucagon secretion ; inversely, anti-TRH serum inhibits glucose plus arginine induced glucagon secretion and produces a concomitant slight inhibition of somatostatin secretion
Usman et al., Horm Metab Res 1986
(Hypoglycemia) :
Based on the fact that human pancreas has thyrotropin releasing hormone (TRH) immunoreactivity and bioactivity, we studied the
effect of
TRH on peripheral plasma levels of pancreatic
glucagon ( IRG ) and insulin ( IRI ) in healthy subjects
Knudtzon et al., Horm Metab Res 1985
:
Involvement of the autonomic nervous system in the in vivo
TRH induced increases in the plasma levels of
glucagon , insulin and glucose in rabbits ... The
effects of
TRH `` Roche '' on the plasma levels of
glucagon , insulin and glucose can not be explained by increases in the plasma levels of catecholamines
Fedotov et al., Probl Endokrinol (Mosk) 1985
:
TRH stimulated insulin and
glucagon secretion within the range of the above doses
Knudtzon et al., Horm Metab Res 1981
:
Moreover, TRH immunological and biological activities have been demonstrated in the pancreatic islets, but experiments with isolated rat pancreas have failed to show any direct stimulatory
effect of
TRH on
glucagon and insulin release
Fragner et al., Biochem Biophys Res Commun 1998
(Hypothyroidism) :
TRH stimulates the
glucagon secretion and attenuates exocrine pancreatic secretions