Guo et al., J Biol Chem 2002
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In addition, we demonstrate that binding of HNF-4alpha to the transcriptional coactivator, PC4, in the presence of oxidative stress and interleukin-1beta stimulation is essential for increased iNOS promoter activity in this setting
Marroquin et al., Surgery 2005
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Redox mediated upregulation of transcription of hepatocyte inducible nitric oxide synthase (iNOS) requires hepatocyte nuclear factor IV-alpha ( HNF-4alpha ) ... We hypothesized that PC4 is a necessary component of HNF-4alpha regulated redox-sensitive hepatocyte iNOS transcription ... Redox mediated upregulation of hepatocyte iNOS transcription requires an HNF-4alpha-PC4 transcriptional complex
Gonzalez et al., Biochem J 2006
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A specific phosphorylation by p38 kinase at Ser-158 of HNF4alpha results in increased binding of HNF4alpha to the iNOS promoter, leading to enhanced transcription