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SPHK1 — TNF

Text-mined interactions from Literome

Xia et al., J Biol Chem 1999 (Arteriosclerosis) : We now show that HDL profoundly inhibit TNF stimulated sphingosine kinase activity in endothelial cells resulting in a decrease in sphingosine 1-phosphate production and adhesion protein expression
Vann et al., J Biol Chem 2002 (Glioma) : TNF-alpha also stimulates sphingosine kinase , the enzyme that phosphorylates sphingosine to form sphingosine-1-phosphate ( SPP ), a further metabolite of ceramide
Taha et al., J Biol Chem 2005 : Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism
Mastrandrea et al., Diabetes 2005 : IL-1beta or TNF-alpha increased islet SPHK activity within 15 min to 1 h ; activity remained elevated after 8 h. SPHK2 was the predominant active isoform in INS-1 cells ; little or no SPHK1 activity was detected ... Compared with basal values, IL-1beta and TNF-alpha induced increases in SPHK1a mRNA levels relative to 18S ribosomal RNA in INS-1 cells within 1 h ; relative SPHK2 mRNA levels were unchanged after cytokine treatment ... Thus, IL-1beta and TNF-alpha induced an early and sustained increase in SPHK activity in INS-1 cells and isolated islets, suggesting that S1P plays a role in the pathological response of pancreatic beta-cells to cytokines
Billich et al., Cell Signal 2005 : Using human A549 epithelial lung carcinoma cells as a model system, we observed transient upregulation of sphingosine kinase type 1 (SPHK1) enzyme activity upon stimulation with both TNF-alpha or IL-1beta
Yang et al., J Immunol 2005 : Consistently, overexpression of dominant negative SPHK1 increased the production of IL-2, TNF-alpha , and IFN-gamma in Th1 cells
Bu et al., FASEB J 2006 : Furthermore, experiments using SphK1 specific siRNA demonstrated that SphK1 is required for the TNF-alpha stimulation of MMP1
Zhi et al., J Cell Physiol 2006 (Inflammation) : We show that TNFalpha rapidly triggers S1P generation and activation of SPHK
Radeff-Huang et al., J Biol Chem 2007 (Brain Neoplasms...) : Tumor necrosis factor-alpha (TNF-alpha) has been shown to activate sphingosine kinase ( SphK ) in a variety of cell types ... Signaling mechanisms through which SphK mediated the effect of TNF-alpha on DNA synthesis were then examined
Chandru et al., Gene 2007 : Dimethylsphingosine, an inhibitor of sphingosine kinase , partially inhibited TNF-alpha induction of IL-8 mRNA levels indicating the importance of intracellular increases in S1-P in the IL-8 induction
Nayak et al., Neuroscience 2010 (Encephalitis...) : Suppression of SphK1 by its inhibitor, N, N Dimethylsphingosine ( DMS ), or siRNA resulted in decreased mRNA expression of TNF-alpha , IL-1beta, and iNOS and release of TNF-alpha and nitric oxide ( NO ) in LPS activated microglia
Alvarez et al., Nature 2010 : These results also highlight the key role of SphK1 and its product S1P in TNF-alpha signalling and the canonical NF-kappaB activation pathway important in inflammatory, antiapoptotic and immune processes
Gurgui et al., Cell Signal 2010 : Although our experimental data clearly show the mediatory role of sphingosine kinase ( SK ) -derived S1P in the TNF-alpha and the LPS induced activation of NF-kB, exogenously added S1P failed to trigger this transcription factor
Scherer et al., Stroke 2010 (Hearing Loss) : TNF-a activated sphingosine kinase 1 (Sk1) and induced its translocation to the smooth muscle cell membrane