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HDAC7 — HIF1A

Pathways - manually collected, often from reviews:

• NCI Pathway Database HIF-1-alpha transcription factor network: Cbp/p300/CITED2 complex (EP300_CREBBP-CITED2) → HIF1A/ARNT/Cbp/p300/HDAC7 complex (HIF1A-ARNT-EP300_CREBBP-HDAC7) (modification, collaborate)
  Lando et al., Science 2002, Hewitson et al., J Biol Chem 2002, Kato et al., J Biol Chem 2004, Arany et al., Proc Natl Acad Sci U S A 1996, Kallio et al., EMBO J 1998, Bhattacharya et al., Genes Dev 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: HIF1A/ARNT complex (HIF1A-ARNT) → HIF1A/ARNT/Cbp/p300/HDAC7 complex (HIF1A-ARNT-EP300_CREBBP-HDAC7) (modification, collaborate)
  Lando et al., Science 2002, Hewitson et al., J Biol Chem 2002, Kato et al., J Biol Chem 2004, Arany et al., Proc Natl Acad Sci U S A 1996, Kallio et al., EMBO J 1998, Bhattacharya et al., Genes Dev 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: HIF1A/ARNT complex (HIF1A-ARNT) → HDAC7 (HDAC7) (modification, collaborate) Lando et al., Science 2002, Hewitson et al., J Biol Chem 2002, Kato et al., J Biol Chem 2004, Arany et al., Proc Natl Acad Sci U S A 1996, Kallio et al., EMBO J 1998, Bhattacharya et al., Genes Dev 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: nucleus (EP300/CREBBP) → HIF1A/ARNT/Cbp/p300/HDAC7 complex (HIF1A-ARNT-EP300_CREBBP-HDAC7) (modification, collaborate)
  Lando et al., Science 2002, Hewitson et al., J Biol Chem 2002, Kato et al., J Biol Chem 2004, Arany et al., Proc Natl Acad Sci U S A 1996, Kallio et al., EMBO J 1998, Bhattacharya et al., Genes Dev 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: HIF1A/ARNT/Cbp/p300/HDAC7 complex (HIF1A-ARNT-EP300_CREBBP-HDAC7) → HIF1A (HIF1A) (modification, collaborate) Lando et al., Science 2002, Hewitson et al., J Biol Chem 2002, Kato et al., J Biol Chem 2004, Arany et al., Proc Natl Acad Sci U S A 1996, Kallio et al., EMBO J 1998, Bhattacharya et al., Genes Dev 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: HIF1A/ARNT/Cbp/p300/HDAC7 complex (HIF1A-ARNT-EP300_CREBBP-HDAC7) → CITED2 (CITED2) (modification, collaborate) Lando et al., Science 2002, Hewitson et al., J Biol Chem 2002, Kato et al., J Biol Chem 2004, Arany et al., Proc Natl Acad Sci U S A 1996, Kallio et al., EMBO J 1998, Bhattacharya et al., Genes Dev 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: HIF1A/ARNT/Cbp/p300/HDAC7 complex (HIF1A-ARNT-EP300_CREBBP-HDAC7) → HDAC7 (HDAC7) (modification, collaborate) Lando et al., Science 2002, Hewitson et al., J Biol Chem 2002, Kato et al., J Biol Chem 2004, Arany et al., Proc Natl Acad Sci U S A 1996, Kallio et al., EMBO J 1998, Bhattacharya et al., Genes Dev 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: HIF1A/ARNT/Cbp/p300/HDAC7 complex (HIF1A-ARNT-EP300_CREBBP-HDAC7) → HIF1A/ARNT/Cbp/p300 complex (HIF1A-ARNT-EP300_CREBBP) (modification, collaborate)
  Lando et al., Science 2002, Hewitson et al., J Biol Chem 2002, Kato et al., J Biol Chem 2004, Arany et al., Proc Natl Acad Sci U S A 1996, Kallio et al., EMBO J 1998, Bhattacharya et al., Genes Dev 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: HIF1A (HIF1A) → HDAC7 (HDAC7) (modification, collaborate) Lando et al., Science 2002, Hewitson et al., J Biol Chem 2002, Kato et al., J Biol Chem 2004, Arany et al., Proc Natl Acad Sci U S A 1996, Kallio et al., EMBO J 1998, Bhattacharya et al., Genes Dev 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: HDAC7 (HDAC7) → HIF1A/ARNT/Cbp/p300 complex (HIF1A-ARNT-EP300_CREBBP) (modification, collaborate)
  Lando et al., Science 2002, Hewitson et al., J Biol Chem 2002, Kato et al., J Biol Chem 2004, Arany et al., Proc Natl Acad Sci U S A 1996, Kallio et al., EMBO J 1998, Bhattacharya et al., Genes Dev 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: HIF1A/ARNT/Cbp/p300/HDAC7 complex (HIF1A-ARNT-EP300_CREBBP-HDAC7) → GLUT1 (SLC2A1) (transcription, activates) Hu et al., Mol Cell Biol 2003, Kato et al., J Biol Chem 2004, Iyer et al., Genes Dev 1998
  Evidence: mutant phenotype, assay
• NCI Pathway Database HIF-1-alpha transcription factor network: HIF1A/ARNT/Cbp/p300/HDAC7 complex (HIF1A-ARNT-EP300_CREBBP-HDAC7) → VEGFA (VEGFA) (transcription, activates) Hu et al., Mol Cell Biol 2003, Kato et al., J Biol Chem 2004, Gradin et al., Mol Cell Biol 1996, Arany et al., Proc Natl Acad Sci U S A 1996
  Evidence: mutant phenotype, assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HIF1A — HDAC7 (physical association, affinity chromatography technology) Bodily et al., Cancer Res 2011*

Text-mined interactions from Literome

Kato et al., J Biol Chem 2004 (Anoxia) : In the nucleus, HDAC7 increased transcriptional activity of HIF-1alpha through the formation of a complex with HIF-1alpha , HDAC7, and p300 ... Taken together, these results indicate that HDAC7 is a novel transcriptional activator of HIF-1alpha
Kim et al., Int J Oncol 2006 : We next tested the possible involvement of HDAC7 or OS-9 in YC-1 induced HIF-1alpha degradation
Kim et al., Oncol Rep 2007 (Anoxia...) : Here, we found that a histone deacetylase inhibitor, sodium butyrate, inhibits the hypoxia induced induction and activity of HIF-1alpha in HT1080 human fibrosarcoma cells