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MMP11 — PDGFB
Text-mined interactions from Literome
Karakiulakis et al., J Biol Chem 2007
(Anoxia) :
PDGF-BB inhibited the synthesis and secretion of all hypoxia dependent
MMP via Erk1/2 mitogen activated protein ( MAP ) kinase activation
Liu et al., Neurol Res 2008
(Disease Models, Animal...) :
So,
PDGF-B may
induce the expression of
MMP for the degradation of collagen type III on the wall of the saccular aneurysms
Singer et al., Eur J Biochem 1999
:
Three categories of gene expression were identified : ( a ) MMP-13, -15 and -16 mRNAs were not detected despite stimulation by various cytokines ; ( b ) MMP-2 and -14 as well as TIMP-1, -2 and -3 mRNAs were constitutively expressed but not markedly affected by the six cytokines tested ; ( c ) mRNAs for MMP-1, -9 and -11 were selectively induced by specific cytokines : insulin-like growth factor-II, epidermal growth factor (EGF),
platelet derived growth factor (PDGF)-BB and interleukin (IL)-6
stimulated MMP-11 expression ; MMP-1 was induced by EGF, PDGF-BB, tumour necrosis factor (TNF)alpha and IL-1alpha, which also exerted additive effects