Gene interactions and pathways from curated databases and text-mining

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TLR1 — TLR6

Pathways - manually collected, often from reviews:

  • KEGG Tuberculosis: HSPA9 → Complex of TLR1-TLR2-TLR6 (protein-protein, activation)
  • KEGG Tuberculosis: Complex of TLR1-TLR2-TLR6 → MYD88 (protein-protein, activation)
  • NCI Pathway Database Endogenous TLR signaling: TLR6 (TLR6) → VCAN/TLR2/TLR1 complex (TLR2-TLR1-VCAN) (modification, collaborate)
    Kim et al., Nature 2009
    Evidence: physical interaction

Text-mined interactions from Literome

Bayas et al., Clin Exp Immunol 2009 (Bacterial Infections...) : In peripheral blood mononuclear cells, TLR-9 stimulation with type A CpG ODN resulted in a higher expression of TLR-1 , -2, -4, -5 and -8 in MS patients ( n = 7 ) compared with healthy controls ( n = 11 )
Goethals et al., Glia 2010 (Wallerian Degeneration) : Upon axotomy, TLR1 becomes strongly induced , while most other TLR expression levels remain unaffected
Yang et al., Bing Du Xue Bao 2011 (Marek Disease...) : By comparing the TLRs transcription between YL040920 and CVI988/Rispens infected microglia, it was suggested that vvMDV YL040920 might induce more TLR15 transcript than the attenuated vaccine strain CVI988/Rispens ( P < or = 0.01/0.001 ), while CVI988/Rispens induced more TLR1LB transcript than YL040920 ( P < or = 0.001 )
Charavaryamath et al., Gut microbes 2011 : Finally, Toll-like receptor (TLR)-4 expression was decreased but TLR-5 and -6 expression increased in ileal segments