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PRDX2 — TP53

Text-mined interactions from Literome

Wang et al., Chin J Cancer 2002 (Glioma) : Expression patterns of accumulation of highly acetylated histone H3, H4 ; p53 and cell cycle associated p21waf, p27 which were induced by TSA were determined by using Western blot analysis
Flørenes et al., Melanoma Res 2004 (Melanoma) : TSA significantly induced protein expression of the cyclin dependent kinase inhibitor p21 ( WAF1/CIP1 ) in a dose dependent manner in all cell lines including those not expressing p21 ( WAF1/CIP1 ) constitutively, whereas the levels of both wild-type and mutated p53 protein were reduced
Peltonen et al., Pigment Cell Res 2005 (Melanoma) : TSA stabilized wild-type p53 , but p53 protein accumulation was overridden by simultaneous downregulation of p53 mRNA leading to a decrease in p53 protein ... Inhibiting p53 function by a dominant negative p53 ( p53 ( 175His ) ) confirmed that the HDAC inhibitor induced apoptosis was independent of wild-type p53, even though TSA slightly activated p53 in a reporter assay
Solomon et al., Mol Cell Biol 2006 : Acetyl-p53 was also increased by the histone deacetylase (HDAC) class I/II inhibitor trichostatin A (TSA)
Huang et al., Neurosci Lett 2006 : Trichostatin (TSA) , a p53 inhibitor , can block the effects of tolbutamide, lending further support for a role of p53 in mediating this process
Zhang et al., Oncol Rep 2006 (Stomach Neoplasms) : TSA increases the expression of p21, p53 , DAPK-1 and the DAPK-2 gene in both OCUM-8 and MKN-74 cells
Okamoto et al., J Atheroscler Thromb 2006 : TSA treatment also induced the expression of p21 ( WAF1 ) but not of p16(INK4), p27 ( KIP1 ) or p53
Habold et al., J Cell Mol Med 2008 (Colonic Neoplasms) : Reduced p53 triggered transactivation of p21 ( WAF1 ) in late response allows cells to re-enter cell cycle, and TSA causes p53 to simultaneously induce apoptosis
Dong et al., American journal of physiology. Renal physiology 2010 : Mechanistically, SAHA inhibited and TSA delayed p53 phosphorylation, acetylation, and activation during cisplatin incubation
Torres et al., Int J Oncol 2010 (Neuroblastoma) : In this study, we investigated the effect of trichostatin A or TSA ( an HDAC inhibitor ), and epoxomycin ( a proteasome inhibitor ) on MYCN and p53 expression in MYCN amplified neuroblastoma cells
Mizuno et al., Am J Physiol Lung Cell Mol Physiol 2011 (Pulmonary Emphysema) : TSA suppressed hypoxia-inducible factor-1a (HIF-1a), VEGF, and lysyl oxidase (LOX) and increased microtubule associated protein-1 light chain 3 ( LC3 ), p53 , and miR34a microRNA expression in both rat lungs and cultured HPMVEC
Chan et al., PloS one 2013 (Lung Neoplasms) : In addition, quercetin significantly increased TSA induced p53 expression in A549 cells