Ivanov et al., Exp Cell Res 2006
(Melanoma) :
Furthermore, silencing COX-2 expression by specific RNAi also effectively increased surface FasL expression following arsenite treatment
O'Callaghan et al., Br J Cancer 2008
(Colonic Neoplasms) :
Suppression of either COX-2 or COX-1 by RNA interference in HCA-7 and HT29 colon tumour cells reduced FasL expression at both the mRNA and protein level
Chen et al., Free Radic Biol Med 2009
(Inflammation) :
In addition to CICD, FasL also induces cyclooxygenase-2 and MIP-2 gene upregulation, and both responses are attributed to ROS dependent JNK activation