Xiao et al., Eur J Immunol 1999
:
FasL promoter activation by IL-2 through SP1 and NFAT but not Egr-2 and Egr-3
Kavurma et al., J Biol Chem 2001
:
Sp1 activates the FasL promoter via a distinct nucleotide recognition element whose integrity is crucial for inducible expression ... Inducible FasL promoter activation is also inhibited by a dominant negative form of Sp1 Xiao et al., Eur J Immunol 2001
:
Sp1 is the major fasl gene activator in abnormal CD4 ( - ) CD8 ( - ) B220 ( + ) T cells of lpr and gld mice ... Ectopic expression of Egr-3 but not Sp1 protein in the abnormal DN T cells enhanced fasl promoter activity, suggesting that the Egr but not Sp1 was limiting for fasl gene activation
Kavurma et al., J Biol Chem 2002
(Arteriosclerosis) :
Sp1 induction of the FasL promoter was abrogated by an Ets-1 mutant lacking the activation domain
Savickiene et al., Int J Biochem Cell Biol 2005
(Leukemia) :
p21 ( Waf1/Cip1 ) and FasL gene activation via Sp1 and NFkappaB is required for leukemia cell survival but not for cell death induced by diverse stimuli