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MMP3 — TNFSF12

Text-mined interactions from Literome

Wako et al., J Orthop Res 2007 (Intervertebral Disc Displacement) : In disc tissues derived from TNF-alpha receptor 1- or TNF-alpha receptor 2-deficient mice, recombinant TWEAK modestly induced MMP-3 ... The data suggest that TWEAK plays a role in MMP-3 up-regulation and aggrecan down-regulation in disc tissues, resulting in proteoglycan degradation and promotion of disc degeneration
Wako et al., Spine (Phila Pa 1976) 2008 : To investigate the role of tumor necrosis factor-like weak inducer of apoptosis ( TWEAK ) in matrix metalloproteinase 3 (MMP-3) pathway induction, and the effect of TWEAK to induce other cytokines or angiogenesis factors in disc tissues ... TWEAK induced MMP-3 upregulation and aggrecan downregulation in disc tissues ... Enzyme Linked ImmunoSorbent Assay ( ELISA ), western blot, and immuno-histologic analyses were used to assess the role of TWEAK induced MMP-3 , using murine disc tissue culture ... TWEAK plays an important role in MMP-3 induction in murine disc cells via JNK that results in degradation of disc matrix
Xia et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2009 (Arthritis, Rheumatoid) : To investigate the effects of TWEAK on the synthesis of MMP-3 in RA FLS at different concentrations and to discuss the relative mechanism of how TWEAK involves in the destruction of articular bone and cartilage ... The level of MMP-3 induced by TWEAK at 50 and 100 microg/L was higher than that in control group, which had significant statistic difference ( P < 0.05 ) .The expression level of MMP-3mRNA induced by TWEAK at 100 microg/L was 1.26 times higher than that in the control group, which had significant statistic difference ( P < 0.05 ) .TNF-alpha and IL-1beta had synergetic effect on the synthesis and mRNA expression of MMP-3 ... TWEAK can induce RA FLS to synthesize MMP-3 and damage the articular bone and cartilage directly
Ebihara et al., Exp Eye Res 2009 : TWEAK also increased the production of MMP-1 and -3 by corneal myofibroblasts via Fn14, while TGF-beta(1) inhibited this effect of TWEAK on MMP production