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CALM3 — PLN

Text-mined interactions from Literome

Xu et al., J Biol Chem 2000 : Endogenous CaM kinase mediated phosphorylation of Ca ( 2+ ) -ATPase, phospholamban , and ryanodine receptor-Ca ( 2+ ) release channel was also strongly inhibited by CaM BP
Yang et al., Circ Res 2003 (Calcium Signaling) : Surprisingly, overexpression of CaM ( 1-4 ) increased CaMKII activity and phosphorylation of PLB-Thr-17 ... Moreover, CaM ( 1-4 ) elevated diastolic Ca2+ and caffeine-labile Ca2+ content of the SR. Inhibition of CaMKII by KN-93 or a myristoylated autocamtide-2 related inhibitory peptide prevented the aforementioned PLB phosphorylation and reversed the positive inotropic and relaxant effects, indicating that CaMKII is essential to CaM ( 1-4 ) actions
Gao et al., Biochim Biophys Acta 1992 : This interaction, relevant to the mechanism of calmodulin dependent phosphorylation of phospholamban that relieves its inhibitory influence on the calcium pump, provides a useful model system for comparative study of the properties of calmodulin binding domains
James et al., Nature 1989 : The calcium pump is activated by cyclic AMP- and calmodulin dependent phosphorylation of phospholamban , an integral membrane protein of the sarcoplasmic reticulum
Karczewski et al., Biomed Biochim Acta 1986 : Indirect technique for the estimation of cAMP dependent and Ca2+/calmodulin dependent phospholamban phosphorylation state in canine heart in vivo ... This method allows the separate detection of cAMP dependent and Ca2+/calmodulin dependent phospholamban phosphorylation
Lindemann et al., J Biol Chem 1985 : This study was conducted to determine if Ca2+-calmodulin dependent phosphorylation of phospholamban occurs in response to physiologic increases in intracellular Ca2+ in intact myocardium ... Ca2+-calmodulin dependent phosphorylation of phospholamban may occur in response to agents which stimulate cAMP dependent mechanisms in intact myocardium
Will et al., Experientia 1985 : Phylogenetic changes are indicated by marked differences among species in cardiac phospholamban content and by the absence of Ca2+/calmodulin dependent phospholamban phosphorylation at an early developmental stage
Davis et al., J Biol Chem 1983 : These results were found to be specific for calcium-calmodulin dependent phosphorylation of phospholamban
Tada et al., J Mol Cell Cardiol 1983 : To elucidate the role of 22000-dalton protein phospholamban, a putative regulator of Ca2+ dependent ATPase of cardiac sarcoplasmic reticulum, we examined the relationship between cyclic AMP- and calmodulin dependent phosphorylation of phospholamban and their effects on ATPase activity and calcium transport of cardiac sarcoplasmic reticulum ... Cyclic AMP dependent phosphorylation of phospholamban was independent of Ca2+, whereas calmodulin dependent phosphorylation of phospholamban was dependent on Ca2+ within a range between 0.2 and 50 microM ... Cyclic AMP- and calmodulin dependent phosphorylation of phospholamban occurred independently ; when both kinases were operative, the amounts of phosphorylation were additive ... The ATPase activity was stimulated by either cyclic AMP- or calmodulin dependent phosphorylation of phospholamban at Ca2+ concentrations up to 2 microM ... Calcium uptake was similarly augmented by cyclic AMP- and/or calmodulin dependent phosphorylation of phospholamban
Cavadore et al., Biochimie 1981 : Beside a direct trigger of sarcomeric muscle contraction through binding of troponin C, calcium ions trigger or modulate contractility through calcium-calmodulin dependent myosin light chain kinases, and increase the rate of relaxation through the calmodulin dependent phosphorylation of phospholamban , the activator of the cardiac sarcoplasmic reticulum calcium pump
Strasburg et al., Biochim Biophys Acta 1993 : However, similar concentrations of chymotrypsin resulted in a loss of both calmodulin affinity labeling and calmodulin dependent phosphorylation of phospholamban ( at Thr-17 ) ... These data suggest that binding of calmodulin to phospholamban may be an essential intermediate step in the calmodulin dependent phosphorylation of phospholamban
Odermatt et al., J Biol Chem 1996 : The vmax of the Ca2+-ATPase of cardiac sarcoplasmic reticulum ( SERCA2a ) is not altered by Ca2+/calmodulin dependent phosphorylation or by interaction with phospholamban
Xu et al., J Mol Cell Cardiol 1997 : Phosphorylation studies revealed the presence of CaM kinase dependent phosphorylation of the Ca2+ pump, Ca2+ release channel and phospholamban as early as 21-days gestation