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MSK10 — WNK1
Text-mined interactions from Literome
Vanden Berghe et al., Cancer Res 2006
(MAP Kinase Signaling System) :
This occurs via attenuation of mitogen activated protein/extracellular signal regulated kinase ( ERK ) kinase ( MEK ) and ERK activity, which further down-regulates
MSK dependent NF-kappaB
p65 and histone H3 phosphorylation
Joo et al., J Biol Chem 2008
(Lung Neoplasms) :
We further show that inhibition of
MSK1 , a kinase acting downstream of MEK1/2-ERK1/2, by H89 or knockdown of MSK1 expression also
inhibited phosphorylation of
p65/RelA ( Ser ( 276 ) ), suggesting that this phosphorylation is dependent on MSK1
Reber et al., PloS one 2009
(Inflammation) :
We show here that the MAPK downstream nuclear kinase
MSK1 induces NF-kappaB
p65 Ser276 phosphorylation upon IL-1beta treatment, which was inhibited in cells transfected with a MSK1 kinase-dead ( KD ) mutant compared to the WT control
Yang et al., Free Radic Biol Med 2011
:
Like a JNK inhibitor, darbepoetin alfa did not affect I?Ba degradation or
p65 nuclear translocation, but did
inhibit mitogen- and stress activated protein kinase 1 (
MSK1 ) activation and attenuated p65 phosphorylation ( serine 276 ), effects that may account for the reduction in NF-?B DNA binding activity