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CPOX — IL6
Text-mined interactions from Literome
Moore et al., J Appl Physiol 2001
:
In human cultured airway smooth muscle cells,
interleukin (IL)-1 beta
increases cyclooxygenase (COX)-2 expression and PGE ( 2 ) release, ultimately resulting in decreased beta-adrenergic responsiveness
Moon et al., Toxicol Appl Pharmacol 2003
:
The purpose of this investigation was to test the hypothesis that the inducible
cyclooxygenase-2 (COX-2) and its metabolites
contribute to VT-induced
IL-6 upregulation ... Superinduction of lipopolysaccharide (LPS) mediated IL-6 production by VT in these cells was significantly
reduced by the
COX inhibitors indomethacin and NS-398, whereas the inhibitors did not affect direct induction of
IL-6 by LPS alone
Bukata et al., J Orthop Res 2004
(Osteolysis...) :
Interestingly,
COX-2 was also
required for
IL-6 production in these assays, which could be rescued by the addition of exogenous PGE2 ( 10 ( -6 ) M )
Helmersson et al., Free radical research 2005
(Cardiovascular Diseases...) :
This study investigated the longitudinal association between serum selenium ( s-Se ) and a golden standard indicator of oxidative stress in vivo ( 8-iso-prostaglandin F2alpha, a major F2-isoprostane ), an indicator of
cyclooxygenase (COX) mediated inflammation ( prostaglandin F2alpha ), high sensitive C-reactive protein ( hsCRP ),
interleukin-6 (IL-6) and serum amyloid A protein (SAA) in a follow-up study of 27 years
Chen et al., J Immunol 2006
:
PGN mediated
IL-6 production was
inhibited by a nonselective
cyclooxygenase (COX) inhibitor ( indomethacin ), a selective COX-2 inhibitor ( NS398 ), a PGE ( 2 ) ( EP2 ) antagonist ( AH6809 ), a PGE ( 4 ) ( EP4 ) antagonist ( AH23848 ), and a protein kinase A (PKA) inhibitor ( KT5720 ), but not by a nonselective NO synthase inhibitor ( N ( G ) -nitro-l-arginine methyl ester )
Herseth et al., Toxicol In Vitro 2009
:
Role of IL-1 beta and
COX2 in silica induced
IL-6 release and loss of pneumocytes in co-cultures ... In this study we investigated the
role of IL-1 beta, TNF-alpha and
COX2 in silica induced regulation of
IL-6 release and pneumocyte loss in various mono- and co-cultures of monocytes, pneumocytes and endothelial cells ... Inhibition of
COX2 markedly
reduced both IL-1 beta and
IL-6 release
Li et al., Glia 2011
:
Nonselective and
COX2-selective inhibitors
blocked TLR3 induction of TNFa and
IL-6
Yoon et al., PloS one 2011
(Graves Disease...) :
Quercetin significantly attenuated intercellular adhesion molecule-1 ( ICAM-1 ), interleukin (IL) -6, IL-8, and
cyclooxygenase (COX) -2 mRNA expression, and
inhibited IL-1ß induced increases in ICAM-1,
IL-6 , and IL-8 mRNA
Arslan et al., Prostaglandins 1996
:
In these cells,
COX-2 gene expression was
inducible by the cytokines interleukin-1 beta and tumor necrosis factor alpha, but not by
interleukin-6
Dean et al., J Biol Chem 1999
:
We have previously shown that the pyridinyl imidazole SB 203580, which inhibits it, blocks the
interleukin-1 induction of
cyclooxygenase-2 (COX-2) and matrix metalloproteinase 1 and 3 mRNAs in fibroblasts