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IL6 — SHC1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of ERBB2-SHC1 → IL6 (increases) Qiu et al., Nature 1998*
  Evidence: Two tyrosine-phosphorylated proteins around 190K are co-precipitated with Shc in IL-6-treated cells. These two proteins can be recognized by ErbB2 and ErbB3 antibodies, respectively (Fig. 1c),
• OpenBEL Selventa BEL large corpus: SHC1 → IL6 (increases) Qiu et al., Nature 1998*
  Evidence: When LNCaP cells were treated with IL6 Erbb3 and Erbb2 proteins were tyrosine phosphorylated. With them all the three isoforms of Shc proteins were also phosphorylated.
• BioCarta il 6 signaling pathway: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  

Text-mined interactions from Literome

Matsuguchi et al., J Biol Chem 1994 (Leukemia, Megakaryoblastic, Acute) : Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony stimulating factor, interleukin-3 , and steel factor and is constitutively increased by p210BCR/ABL
Neumann et al., Eur J Immunol 1996 (Multiple Myeloma) : Interleukin-6 induces tyrosine phosphorylation of the Ras activating protein Shc , and its complex formation with Grb2 in the human multiple myeloma cell line LP-1 ... In the multiple myeloma cell line LP-1, IL-6 stimulated the tyrosine phosphorylation of Shc in a time- and concentration dependent manner
Berger et al., Blood 1997 (Multiple Myeloma) : Prior treatment of U266 cells with IFN-beta downregulated IL-6 induced tyrosine phosphorylation of gp130, Jak2, PTP1D/Syp, Shc , and Erk2, and GTP loading of p21ras ... Further analysis indicated that treatment with IFN-beta disrupted IL-6 induced binding of PTP1D/Syp to gp130 and the adaptor protein Grb2 ; IFN-beta pretreatment also interfered with IL-6 induced interaction of Shc with Grb2 and a 145-kD tyrosine phosphorylated protein
Giordano et al., J Immunol 1997 : Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase
Ogata et al., J Immunol 1997 (Multiple Myeloma) : In contrast, IL-6 induced phosphorylation of Shc and its association with Sos1, as well as phosphorylation of MAPK, only in MM cells and B9 cells that proliferated in response to IL-6