◀ Back to ATF4
ATF4 — EIF2S1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
ATF4
→
EIF2S1
(increases, EIF2S1 Activity)
Evidence: Paradoxically, phosphorylated eIF2-alpha enhances the translation of the activating-transcription-factor-4, which is involved in the induction of stress-responsive genes.
-
KEGG Protein processing in endoplasmic reticulum:
EIF2S1
→
ATF4
(protein-protein, activation)
Text-mined interactions from Literome
Roybal et al., J Biol Chem 2005
:
Arsenite induced
eIF2alpha phosphorylation, resulting in increased
ATF4 protein
levels
Latreille et al., J Biol Chem 2006
:
We show that overexpression of Nck decreases basal and ER stress induced
eIF2alpha phosphorylation and the attendant
induction of
ATF4 and CHOP
Yamauchi et al., Brain Res 2007
(Disease Models, Animal...) :
ATF4 , which is specifically
activated by
PERK-eIF2alpha , was induced only in interneurons between 6 h and 1 day after reperfusion
Armstrong et al., J Biol Chem 2010
(Neuroectodermal Tumors) :
Although PERK dependent phosphorylation of
eIF2alpha enhanced
ATF4 protein levels during ER stress, cell death in response to fenretinide, bortezomib, or thapsigargin was not abrogated by inhibition of eIF2alpha phosphorylation through PERK knockdown or overexpression of wild-type eIF2alpha