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AKT3 — SDCBP

Text-mined interactions from Literome

Hwangbo et al., J Biol Chem 2011 : We report here that mda-9/syntenin , a positive regulator of cancer metastasis, regulates the activation of Akt ( also known as protein kinase B ) by facilitating ILK adaptor function during adhesion to type I collagen ( COL-I ) in human breast cancer cells ... Inhibition of mda-9/syntenin or expression of mutant ILK ( E359K ) significantly blocked the translocation of both ILK and Akt to the plasma membrane ... These results demonstrated that mda-9/syntenin regulates the activation of Akt by controlling the plasma membrane targeting of Akt via a mechanism that facilitates the association of Akt with ILK at the plasma membrane during adhesion to COL-I
Gangemi et al., PloS one 2012 (Disease Progression...) : Moreover, silencing of SDCBP in mda-9/syntenin-high uveal melanoma cells inhibited the hepatocyte growth factor (HGF) triggered invasion of matrigel membranes and inhibited the activation of FAK, AKT and Src
Dasgupta et al., Clin Cancer Res 2013 : MDA-9/Syntenin overexpression in nontumorigenic HUC-1 cells increased proliferation ( P = 0.0012 ), invasion ( P = 0.0001 ), and EGF receptor (EGFR), AKT , phosphoinositide 3-kinase (PI3K), and c-Src expression