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FOXP3 — TGFB1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: FOXP3 → TGFB1 (increases) Fantini et al., J Immunol 2004*
  Evidence: Similarly, TGF-{beta} stimulation regulated Foxp3 expression in anti-CD3/CD28-stimulated human CD4+ T lymphocytes at the mRNA and protein level, suggesting that TGF-{beta} controls expression of this key regulatory protein both in human and murine T cells (Fig. 1, B and C).
• WikiPathways Allograft Rejection: TGFB1 → FOXP3 (activation)

Text-mined interactions from Literome

Luo et al., Proc Natl Acad Sci U S A 2007 (Diabetes Mellitus, Type 1) : Here we show that beta-cell peptide pulsed dendritic cells (DCs) from nonobese diabetic ( NOD ) mice can effectively induce CD4 ( + ) CD25 ( + ) Foxp3 ( + ) T cells from naïve islet-specific CD4 ( + ) CD25 ( - ) T cells in the presence of TGF-beta1
Kim et al., J Exp Med 2007 : Interestingly, transforming growth factor-beta , which induces T reg cell formation, decreases methylation of the CpG island and increases FoxP3 expression
Yamazaki et al., Blood 2007 : With added transforming growth factor ( TGF ) -beta , both immature and mature populations of dendritic cells (DCs) induced antigen-specific Foxp3 ( + ) T regs from Foxp3 ( - ) precursors
Hinz et al., Cancer Res 2007 (Carcinoma...) : Foxp3 expression was induced by transforming growth factor-beta2 ( TGF-beta2 ), but not TGF-beta1 stimulation in these cells, and was partially suppressed following antibody mediated neutralization of TGF-beta2
Lu et al., Mol Cell Biol 2007 : Furthermore, while in vitro analysis suggested a potential involvement of GPR83 in transforming growth factor beta dependent Foxp3 induction , there was no difference in the ability of nonregulatory GPR83-deficient and nondeficient Foxp3- T cells to acquire Foxp3 expression in vivo
Elias et al., Blood 2008 : Conversely, inhibition of retinoic acid signaling constrains transforming growth factor beta ( TGF-beta1 ) induction of FoxP3
Mantel et al., PLoS Biol 2007 : GATA3-driven Th2 responses inhibit TGF-beta1 induced FOXP3 expression and the formation of regulatory T cells ... This inhibitory mechanism was also confirmed in Th2 cells and in T cells of transgenic mice overexpressing GATA-3 in T cells, which are shown to be deficient in transforming growth factor ( TGF ) -beta mediated FOXP3 induction
Takaki et al., J Biol Chem 2008 (Hypersensitivity) : STAT6 Inhibits TGF-beta1 mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor ... We found that TGF-beta1 induced Foxp3 levels were maintained by the addition of the anti-interleukin 4 (IL-4) antibody or by STAT6 gene deletion ... STAT6 binding to this site reduced TGF-beta1 mediated Foxp3 promoter activation and chromatin modification ... Retinoic acid has also been shown to suppress loss of Foxp3 induced by TGF-beta1
Samon et al., Blood 2008 : Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells ... Previous studies have shown that transforming growth factor beta ( TGFbeta1 ) induces Foxp3 expression and a regulatory phenotype in peripheral T cells
Chaput et al., Gut 2009 (Adenocarcinoma...) : Finally, interleukin 6 and TGF beta 1 synergistically induced the generation of CD8 ( + ) CD25 ( + ) Foxp3 ( + ) T cells ex vivo
Shvets et al., Blood 2009 (Lymphopenia) : In irradiated mice undergoing HP, we found that T cells displayed a severe deficit in the activation induced expression of inhibitory molecules PD-1 and CTLA-4, and TGF-beta1 induced expression of Foxp3
Sthoeger et al., Hum Immunol 2009 (Lupus Erythematosus, Systemic) : hCDR1 increased the expression of transforming growth factor ( TGF ) -beta , FoxP3 and the negative regulators Foxj1 and Foxo3a ... hCDR1 increased the expression of transforming growth factor ( TGF ) -beta , FoxP3 and the negative regulators Foxj1 and Foxo3a
Windish et al., J Leukoc Biol 2009 (Inflammation) : While natural T regulatory cells are produced in the thymus, TGF-beta1 signaling combined with T-cell receptor signaling induces the expression of Foxp3 in CD4+ T cells in the periphery ... We found that ICAM-1-/- mice have fewer T regulatory cells in the periphery than WT controls, due to a role for ICAM-1 in induction of Foxp3 expression in response to TGF-beta1
Cao et al., J Biol Chem 2009 (Atherosclerosis) : Mechanistic studies demonstrate that in response to TGF-beta1 , KLF10 can transactivate both TGF-beta1 and Foxp3 promoters, implicating KLF10 in a positive feedback loop that may promote cell-intrinsic control of T cell activation
Chen et al., Journal of molecular cell biology 2010 : In naïve T cells transforming growth factor-beta ( TGF-beta ) induces Foxp3 , a transcription factor essential for programming and developing T regulatory cells ( Treg cells )
Scholzen et al., PLoS Pathog 2009 (Malaria, Falciparum) : Generation of Foxp3 ( hi ), but not Foxp3 ( int ), cells specifically required TGFbeta1 and IL-10
Kushwah et al., J Immunol 2009 : We have shown that in vitro culture of apoptotic DCs with immature DCs, results in their uptake by immature DCs, which subsequently turn into tolerogenic DCs, which then secrete TGF-beta1 and induce Foxp3 ( + ) regulatory T cells ( T ( regs ) )
Xu et al., Mucosal Immunol 2010 : Molecular mechanisms regulating transforming growth factor-beta ( TGF-beta ) induction of Foxp3 ( forkhead box P3 ) expression and thus induction of induced regulatory T cells ( Tregs ) have been the focus of a great deal of study in recent years
Baratelli et al., American journal of translational research 2010 : We and others have previously shown that prostaglandin E2 ( PGE ( 2 ) ) and transforming growth factor beta ( TGF-beta ) induce CD4 ( + ) CD25 ( bright ) FOXP3 ( + ) T ( reg )
Yang et al., BMC complementary and alternative medicine 2012 : The development of these T ( reg ) cells is controlled by the regulator protein Foxp3, which can be enhanced by the in vitro activation of Foxp3 in the presence of transforming growth factor-beta
Lan et al., Journal of molecular cell biology 2012 : We report that polyclonal CD4 ( + ) Foxp3 ( + ) Treg cells induced ex vivo with transforming growth factor beta ( TGFß ) ( iTreg ) suppress a lupus-like chronic graft-versus-host disease by preventing the expansion of immunogenic DCs and inducing protective DCs that generate additional recipient CD4 ( + ) Foxp3 ( + ) cells