Gene interactions and pathways from curated databases and text-mining

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HLA-DRA — RELA

Text-mined interactions from Literome

Kim et al., Biochem Biophys Res Commun 2002 : In addition, we previously found that cross linking of MHC class II molecules using anti-MHC class II antibodies inhibited NF-kappaB activation in resting B cells isolated from mouse spleen
Lee et al., Eur J Immunol 2006 : Direct role of NF-kappaB activation in Toll-like receptor triggered HLA-DRA expression ... Additionally, nuclear factor (NF)-kappaB activation is required for the CpG-DNA activated and LPS activated HLA-DRA expression, whereas IFN-gamma induced MHC-II expression depends on CIITA rather than on NF-kappaB ... Comprehensive mutant analyses, electrophoretic mobility shift assays and chromatin immunoprecipitation assays, reveal that the functional interaction of NF-kappaB with the promoter element is necessary for the TLR mediated HLA-DRA induction by CpG-DNA and LPS
Trede et al., J Immunol 1993 (Leukemia, Monocytic, Acute) : Induction of both NF-kappa B DNA binding proteins and NF-kappa B enhancer function was down-regulated by inhibitors of protein kinase C and protein tyrosine kinase, indicating a role for these protein kinases in the induction of NF-kappa B by MHC class II ligands
Grammer et al., J Immunol 1998 (Burkitt Lymphoma) : By contrast, induction of apoptosis, activation of NF-kappaB , generation of granulocyte-macrophage CSF, and up-regulation of CD54, MHC class II , and CD95 were unaffected by the TRAF3 dominant negative