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BAX — CYP2J2

Text-mined interactions from Literome

Chen et al., J Pharmacol Exp Ther 2009 (Neoplasm Invasiveness...) : Inhibition of CYP2J2 also significantly potentiated human tumor cell apoptosis and caused a corresponding increase in caspase-3 activity and change in expression of apoptosis related proteins Bax and Bcl-2
Feng et al., Int J Mol Med 2013 : Two mechanisms were found to be involved in these important protective effects : firstly, EETs and CYP2J2 overexpression inhibited the decrease in the expression of the antiapoptotic proteins, Bcl-2 and Bcl-xL, as well as the increase in the expression of the pro-apoptotic protein, Bax , mediated by TNF-a ; secondly, they activated the phosphoinositide 3-kinase (PI3K)/Akt and extracellular signal regulated kinase ( ERK ) signaling pathways