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BRCA1 — ESR2
Text-mined interactions from Literome
Hilakivi-Clarke et al., Cancer Res 2000
(Breast Neoplasms...) :
Findings obtained in in vitro assays and animal studies indicate that estrogens might influence the activity of the tumor suppressor gene BRCA1, and
BRCA1 in turn may
suppress the activity of the
estrogen receptor
Fan et al., Oncogene 2001
(Breast Neoplasms) :
Role of direct interaction in
BRCA1 inhibition of
estrogen receptor activity
Zheng et al., Proc Natl Acad Sci U S A 2001
(Adenocarcinoma...) :
BRCA1 mediates ligand independent transcriptional repression of the
estrogen receptor
Fan et al., Cancer Res 2002
(Breast Neoplasms...) :
p300 Modulates the
BRCA1 inhibition of
estrogen receptor activity ... We previously reported that expression of the breast cancer susceptibility gene
BRCA1 strongly
inhibits the transcriptional activity of the
estrogen receptor ( ER-alpha ) in human breast and prostate cancer cell lines but only weakly inhibits ER-alpha activity in cervical cancer cells ( S. Fan et al., Science ( Wash. DC ), 284 : 1354-1356, 1999 )
Ma et al., Mol Endocrinol 2006
:
Previously, the breast cancer susceptibility gene product
BRCA1 was found to interact with and
inhibit the transcriptional activity of
estrogen receptor-alpha ... Whereas down-regulation of the coactivator p300 contributes to the
BRCA1 mediated repression of
estrogen receptor-alpha , this mechanism does not contribute to inhibition of PR activity, because exogenous p300 did not rescue the BRCA1 repression of PR activity
Thasni et al., Eur J Pharmacol 2008
(Ovarian Neoplasms) :
Genistein inhibits estrogen receptor-alpha and activates BARD1 in BRCA1 blocked cells and induces
estrogen receptor-beta and FAS in
presence of
BRCA1
Burga et al., Breast Cancer Res 2011
(Cell Transformation, Neoplastic...) :
Loss of
BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition
prevents estrogen receptor negative cancers in BRCA1-mutant mice