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ESR2 — NOS1
Text-mined interactions from Literome
Zhu et al., Science 2002
(Hypertension) :
In wild-type mouse blood vessels, estrogen attenuates vasoconstriction by an
ERbeta mediated increase in inducible
nitric oxide synthase expression
Simoncini et al., Arterioscler Thromb Vasc Biol 2003
:
By interacting with phosphatidylinositol 3-kinase (PI3K),
estrogen receptor (ER) alpha
leads to activation of protein kinase Akt and to subsequent increase in endothelial
nitric oxide synthase activity
Xia et al., Endocrinology 2004
(Neuroblastoma) :
These results demonstrate that E2-stimulated NO production occurs via
estrogen receptor mediated activation of the constitutive NOSs,
neuronal NOS and eNOS
Gingerich et al., Neuropharmacology 2008
:
Activation of
ERbeta increases levels of phosphorylated
nNOS and NO production through a Src/PI3K/Akt dependent pathway in hypothalamic neurons ... Because phosphorylation of nNOS at Ser ( 1412 ) increases nNOS activity which leads to increased NO production, we investigated the
effects of
ERbeta activation on
nNOS phosphorylation at Ser ( 1412 ) and NO production in primary hypothalamic neurons ... Using the selective ERbeta agonist, DPN ( 10nM ), we show that activation of
ERbeta rapidly
increases phosphorylation levels of
nNOS at Ser ( 1412 ) and NO production ... Finally, we demonstrate that Src kinase acts upstream of the PI3K/Akt pathway based on our finding that the selective Src inhibitor, PP2 ( 10microM ), blocked the increases in
nNOS phosphorylation levels, NO production, and PI3K/Akt activity
induced by
ERbeta activation ... Together, our results show that Src kinase mediates
ERbeta induced increases in phosphorylation levels of
nNOS at Ser ( 1412 ) and NO production by activating the PI3K/Akt pathway
Cignarella et al., J Pharmacol Exp Ther 2009
(Diabetes Mellitus, Experimental...) :
Distinct
roles of
estrogen receptor-alpha and beta in the modulation of vascular inducible
nitric-oxide synthase in diabetes