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BAX — JUN
Text-mined interactions from Literome
Mandal et al., Gastroenterology 2001
(Colorectal Neoplasms) :
BA-induced enhancement of DNA fragmentation and stimulation of
Bax promoter activity were
blocked by the expression of dominant negative mutants of JNK1 or
AP1 but not NF-kappaB
Papadakis et al., FEBS Lett 2006
:
The
regulation of
Bax by
c-Jun N-terminal protein kinase (JNK) is a prerequisite to the mitochondrial induced apoptotic pathway
Zhang et al., J Neurochem 2006
(Brain Ischemia...) :
Subsequently, inhibition of
c-Jun N-terminal kinase 3 ( JNK3 ) results in decreased serine phosphorylation of 14-3-3, a cytoplasmic anchor of Bax, and
prevents ischemia induced mitochondrial translocation of
Bax , release of cytochrome c and activation of caspase 3
Keramaris et al., J Biol Chem 2008
:
Moreover,
Bax deficiency does not
affect c-Jun phosphorylation
Kim et al., FEBS J 2008
(Uterine Cervical Neoplasms) :
In addition, dominant negative form of
c-Jun inhibited radiation induced Fas expression and
Bax and Bak activation
Kim et al., Arch Pharm Res 2009
(Colonic Neoplasms) :
NF-kappaB target gene expression of apoptotic cell death proteins (
Bax , caspase-3, caspase-9 ) was significantly enhanced, but the expression of anti-apoptotic genes and cell proliferation marker genes ( Bcl-2, inhibitor of apoptosis protein ( IAP-1 ) and X chromosome IAP (XIAP), Cox-2, c-Fos,
c-Jun and cyclin D1 ) was significantly
inhibited by the combined treatment compared to Rg3 or docetaxel alone
Byun et al., Mol Pharmacol 2009
(Uterine Cervical Neoplasms) :
We also showed that
c-Jun N-terminal kinase (JNK) is
involved in ROS dependent
Bax activation
Liu et al., Biomaterials 2010
(Necrosis) :
Silica nanoparticles also activated c-Jun N-terminal kinase (JNK),
c-Jun , p53, caspase-3 and NF-kappaB,
increased Bax expression and suppressed Bcl-2 protein
Bergeron et al., Curr Opin Neurobiol 1998
(Nervous System Diseases) :
When neurons are deprived of trophic factors, a sequence of events is initiated, which includes a reduction in macromolecule synthesis, elevation of
c-Jun and cyclin D1, and
activation of
BAX