UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

CASP10 — DAXX

Pathways - manually collected, often from reviews:

BioCarta fas signaling pathway (cd95): FAS/DAXX/FADD/Caspase 10/FAS L complex (FAS-DAXX-FADD-CASP10-FASLG) → FAF1 (modification, collaborate)
BioCarta fas signaling pathway (cd95): FAS/DAXX/FADD/Caspase 10/FAS L complex (FAS-DAXX-FADD-CASP10-FASLG) → FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10) (modification, collaborate)
BioCarta fas signaling pathway (cd95): FAS/DAXX/FADD/Caspase 10/FAS L complex (FAS-DAXX-FADD-CASP10-FASLG) → PTPN13 (modification, collaborate)
BioCarta fas signaling pathway (cd95): FAF1 → FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10) (modification, collaborate)
BioCarta fas signaling pathway (cd95): I-FLICE/RIP2 complex (CFLAR-RIPK2) → FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10) (modification, activates)
BioCarta fas signaling pathway (cd95): FAS/DAXX/FADD/Caspase 10 complex (FAS-DAXX-FADD-CASP10) → FAS/DAXX/FADD/Caspase 10/FAS L complex (FAS-DAXX-FADD-CASP10-FASLG) (modification, collaborate)
BioCarta fas signaling pathway (cd95): FAS/DAXX/FADD/Caspase 10 complex (FAS-DAXX-FADD-CASP10) → TNFSF6 (FASLG) (modification, collaborate)
BioCarta fas signaling pathway (cd95): FAS/DAXX/FADD/Caspase 10/FAS L complex (FAS-DAXX-FADD-CASP10-FASLG) → TNFSF6 (FASLG) (modification, collaborate)
BioCarta fas signaling pathway (cd95): FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10) → Caspase 7 (CASP7) (modification, activates)
BioCarta fas signaling pathway (cd95): FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10) → Caspase 7 (active) (CASP7) (modification, activates)
BioCarta fas signaling pathway (cd95): FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10) → JNKK1 (MAP2K4) (modification, activates)
WikiPathways Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation: DAXX → DAXX/FAS/FADD/FAF1/CASP10 (activation)

Text-mined interactions from Literome

Song et al., J Cell Biochem 2004 : Daxx fragment induced activation of caspase-9 and -3 was mediated through the apoptosis signal regulating kinase 1 ( ASK1 ) -MEK-c-Jun-N-terminal kinase (JNK)/p38-Bax pathway
Kanamori et al., Am J Physiol Heart Circ Physiol 2007 (Myocardial Infarction...) : Ten days post-MI, apoptosis among granulation tissue cells was significantly suppressed in the olmesartan treated hearts, where expression of Fas, Bax, procaspase-3, and Daxx and activation of caspase-3 , c-Jun NH ( 2 ) -terminal kinase, and c-Jun were all significantly attenuated