Kalliolias et al., Arthritis Rheum 2010
(Arthritis, Rheumatoid...) :
IL-27 inhibited human osteoclastogenesis, suppressed the induction of NFATc1, down-regulated the expression of RANK and triggering receptor expressed on myeloid cells 2 ( TREM-2 ), and inhibited RANKL mediated activation of ERK, p38, and NF-kappaB in osteoclast precursors
Robinson et al., J Innate Immun 2010
:
Additionally, IL-27 blocked NF-kappaB activation in response to IL-18