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CXCL9 — RAC1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: RAC1 → CXCL9 (increases, CXCL9 Activity) Robledo et al., J Biol Chem 2001*
  Evidence: the chemokine Mig, a ligand for CXCR3, activates the small GTPases RhoA and Rac1, induces a reorganization of the actin cytoskeleton, and triggers cell chemotaxis and modulation of integrin VLA-5- and VLA-4-dependent cell adhesion to fibronectin.

Text-mined interactions from Literome

Robledo et al., J Biol Chem 2001 (Melanoma...) : Using the highly invasive melanoma cell line BLM, we demonstrate that the chemokine Mig , a ligand for CXCR3, activates the small GTPases RhoA and Rac1 , induces a reorganization of the actin cytoskeleton, and triggers cell chemotaxis and modulation of integrin VLA-5- and VLA-4 dependent cell adhesion to fibronectin
Lin et al., J Biol Chem 2011 : In this study, we further investigated the roles of Rac1 , phosphoinositide 3-kinase (PI3K), and Akt in thrombin induced NF-?B activation and IL-8/CXCL8 expression