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ERBB2 — PRKAR2A

Text-mined interactions from Literome

Yang et al., Arch Pharm Res 2008 (Breast Neoplasms) : We previously reported that cAMP dependent protein kinase (PKA) mediated activator protein-2 (AP-2) activation was responsible for the expression of Her-2/ErbB2 in p53 inactivated mammary epithelial cells ( Yang et al., 2006 ) ... In the present study, we tested the hypothesis that PKA plays a role in the expression of ErbB2 in tamoxifen-resistant breast cancer cells ... In contrast, PKA inhibition by H-89 or cAMP dependent protein kinase inhibitor l gamma overexpression increased the expression levels of ErbB2 in TAM-resistant MCF-7 ( TAMR-MCF-7 ) cells
Monje et al., J Biol Chem 2008 : Here, we report that the activation of protein kinase A (PKA) , but not that of exchange protein activated by cAMP ( EPAC ), enhances S-phase entry of SCs by synergistically enhancing the ligand dependent tyrosine phosphorylation/activation of the neuregulin co-receptor, ErbB2-ErbB3 ... Two basic observations defined the synergistic action of PKA as `` gating '' for neuregulin-ErbB signaling : 1 ) the activation of PKA was not sufficient to induce S-phase entry or the activation of either ErbB2 or ErbB3 ; and 2 ) the presence of neuregulin was strictly required to ignite ErbB activation and thereby ERK and Akt signaling ... However, PKA directly phosphorylated ErbB2 on Thr-686, a highly conserved intracellular regulatory site that was required for the PKA mediated synergistic enhancement of neuregulin induced ErbB2-ErbB3 activation and proliferation in SCs