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BRD8 — RHOA
Text-mined interactions from Literome
Anastasiadis et al., Nat Cell Biol 2000
:
Here we show that
p120 selectively
inhibits RhoA activity in vitro and in vivo
Cozzolino et al., Mol Biol Cell 2003
:
Conversely, we also show that the ectopic expression of full-length
p120 in epithelial cells promotes cytoskeletal changes, stimulates cell motility, and
activates RhoA
Yanagisawa et al., J Biol Chem 2008
(Carcinoma, Renal Cell...) :
However, only the cooperative binding of RhoA to the central
p120 domain and to the alternatively spliced p120 N terminus stabilizes RhoA binding and
inhibits RhoA activity
Alcaide et al., Am J Physiol Cell Physiol 2012
:
Interestingly, overexpression of either p120-4A or
p120-1A dramatically blocked TEM, and overexpression of p120-1A in HUVEC did not
affect RhoA basal activity or activation of RhoA and Rac induced by thrombin or ICAM-1 crosslinking