Gene interactions and pathways from curated databases and text-mining

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BRD8 — RHOA

Text-mined interactions from Literome

Anastasiadis et al., Nat Cell Biol 2000 : Here we show that p120 selectively inhibits RhoA activity in vitro and in vivo
Cozzolino et al., Mol Biol Cell 2003 : Conversely, we also show that the ectopic expression of full-length p120 in epithelial cells promotes cytoskeletal changes, stimulates cell motility, and activates RhoA
Yanagisawa et al., J Biol Chem 2008 (Carcinoma, Renal Cell...) : However, only the cooperative binding of RhoA to the central p120 domain and to the alternatively spliced p120 N terminus stabilizes RhoA binding and inhibits RhoA activity
Alcaide et al., Am J Physiol Cell Physiol 2012 : Interestingly, overexpression of either p120-4A or p120-1A dramatically blocked TEM, and overexpression of p120-1A in HUVEC did not affect RhoA basal activity or activation of RhoA and Rac induced by thrombin or ICAM-1 crosslinking