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NOX3 — SERPINF1

Text-mined interactions from Literome

Yamagishi et al., J Mol Cell Cardiol 2004 : TNF-alpha significantly increased intracellular ROS generation, which was completely blocked by PEDF or diphenylene iodonium, an inhibitor of NADPH oxidase ... Further, PEDF completely prevented the TNF-alpha induced increase in NADPH oxidase activity ... The results demonstrated that PEDF inhibited TNF-alpha induced NF-kappaB activation and subsequent IL-6 overexpression in HUVEC by suppressing NADPH oxidase mediated ROS generation
Yamagishi et al., Cell Tissue Res 2005 : PEDF or diphenylene iodonium, an inhibitor of NADPH oxidase , inhibited Ang-II induced intracellular reactive oxygen species ( ROS ) generation in HUVEC ... Furthermore, PEDF inhibited Ang-II induced up-regulation of mRNA levels of p22phox, Nox4, and gp91phox/Nox2 , which are membrane components of NADPH oxidase, and its enzymatic activity in HUVEC
Yamagishi et al., Med Chem 2006 : Furthermore, PEDF blocked the Ang II-induced reactive oxygen species ( ROS ) generation and NADPH oxidase activity in MOLT-3 T cells
Seki et al., Biochem Biophys Res Commun 2013 (Multiple Myeloma) : PEDF , a glutathione peroxidase mimetic, ebselen, or an inhibitor of NADPH oxidase , diphenylene iodonium significantly inhibited the VEGF induced reactive oxygen species ( ROS ) generation, increase in anti-apoptotic and growth promoting factor, myeloid cell leukemia 1 (Mcl-1) expression, and proliferation in U266 myeloma cells