Gene interactions and pathways from curated databases and text-mining

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IL8 — LTF

Text-mined interactions from Literome

Elass et al., Infect Immun 2002 : Lactoferrin inhibits the lipopolysaccharide induced expression and proteoglycan binding ability of interleukin-8 in human endothelial cells ... Lactoferrin strongly inhibited the interaction of radiolabeled IL-8 to immobilized heparin, whereas a lactoferrin variant lacking the amino acid residues essential for heparin binding was not inhibitory
Willems et al., Immunology 1989 : GCP/IL-8 promoted a dose dependent release of lactoferrin from specific granules but had no effect on enzyme release from primary granules
Shinoda et al., Biosci Biotechnol Biochem 1996 : Effects of lactoferrin and lactoferricin on the release of interleukin 8 from human polymorphonuclear leukocytes
Sorimachi et al., Biochem Mol Biol Int 1997 : Activation of macrophages by lactoferrin : secretion of TNF-alpha, IL-8 and NO ... The effects of lactoferrin on the secretion of TNF-alpha, IL-8 and NO were dose dependent and lactoferrin had a significant effect on secretion of at concentrations greater than 10 mg/ml
Adamik et al., Arch Immunol Ther Exp (Warsz) 1998 (Critical Illness...) : We studied the effect of lactoferrin (LF) on the proliferative response of peripheral blood mononuclear cells ( PBMC ) to lipopolisaccharide (LPS) in vitro and its influence on production of 2 proinflammatory cytokines : interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha)