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AKT2 — TCF12
Text-mined interactions from Literome
Brunet et al., Mol Cell Biol 2001
:
These findings suggest that SGK and
Akt may coordinately
regulate the function of FKHRL1 by phosphorylating this
transcription factor at distinct sites
Hutchinson et al., Mol Cell Biol 2001
(Hyperplasia...) :
Furthermore, coexpression of
Akt-DD with MTY315/322F
resulted in phosphorylation of the FKHR forkhead
transcription factor and translational upregulation of cyclin D1 levels
Patel et al., J Biol Chem 2002
:
The signaling pathway that mediates these events requires the activation of phosphatidylinositol 3-kinase, whereas transfection studies have suggested an involvement of Akt ( protein kinase B ) and FKHR, a
transcription factor regulated by
Akt
Vojtek et al., Mol Cell Biol 2003
:
Akt regulates basic helix-loop-helix
transcription factor-coactivator complex formation and activity during neuronal differentiation
Christian et al., J Biol Chem 2003
:
Preventing Rap activation also increased the ability of the BCR to stimulate
Akt dependent phosphorylation of the FKHR
transcription factor on negative regulatory sites and decreased the levels of p27Kip1, a pro-apoptotic factor whose transcription is enhanced by FKHR
Figueroa et al., Oncogene 2003
:
Here, we show that
Akt regulates the Elk-1
transcription factor , independent of its negative regulation of Raf kinases
Lee et al., Mol Cancer Res 2004
(Breast Neoplasms...) :
Stromal cell derived factor 1alpha ( SDF-1alpha ; CXCL12 ) stimulation of breast cancer cells resulted in phosphoinositide 3-kinase (PI-3K) activation,
AKT phosphorylation, and
activation of the FKHRL1
transcription factor
Smith et al., J Biol Chem 2005
:
Furthermore, DEX mediated inhibition of
LEF/TCF transcriptional activity was attenuated in the
presence of dominant negative forms of either PI3K or protein kinase
B/Akt
Stayrook et al., Endocrinology 2005
(Carcinoma, Hepatocellular) :
Activation of FXR initiated a cascade involving induction of peroxisome proliferator activated receptor alpha and TRB3 expression that is consistent with stimulation of PEPCK gene expression via interference with a pathway that may involve
Akt dependent phosphorylation of Forkhead/winged helix
transcription factor ( FOXO1 )
Fabre et al., J Immunol 2005
:
This persistent activation of PI3K results in the
Akt dependent sequestration of the FoxO
transcription factor , FoxO1, outside the nucleus of T cells interacting with APCs
Maclachlan et al., Int J Radiat Biol 2005
(Radiation Injuries) :
In vitro exposure to FGF-20 increased expression of the Nrf2
transcription factor and oxygen radical scavenging enzymes such as MnSOD,
activated signal transduction pathways ( ERK and
Akt ) and resulted in increased survival of irradiated cells in vitro
Belaiba et al., Mol Biol Cell 2007
(Anoxia) :
Furthermore, inhibition of the phosphatidylinositol 3-kinase (PI3K)/AKT but not extracellular signal regulated kinase 1/2 pathway blocked the hypoxia dependent induction of HIF-1alpha mRNA and HIF-1alpha promoter activity, suggesting involvement of a
PI3K/AKT regulated
transcription factor
Kong et al., Neurol Res 2009
(Huntington Disease) :
The level of active
Akt was significantly elevated in STHdh ( Q111 ) compared to STHdh ( Q7 ) resulting in the phosphorylation of a FKHRL1, a forkhead
transcription factor regulating Bim expression in neuronal cells
Michalek et al., Mol Cell 2008
:
In this issue of Molecular Cell, Yamagata et al. ( 2008 ) identify a role for the protein methyltransferase, PRMT1, in
Akt dependent regulation of the FOXO1
transcription factor and demonstrate another level of control in this critical metabolic and cell survival signaling pathway
Zhang et al., Circ Res 2010
(Diabetes Mellitus) :
Moreover, inhibition of
Akt signaling
attenuated the phosphorylation of forkhead box O
transcription factor ( FOXO)-3a and enhanced atrogin-1 expression, which in turn suppressed BK-ß ( 1 ) protein levels in human CASMCs