Gene interactions and pathways from curated databases and text-mining

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CD8A — IL17A

Text-mined interactions from Literome

Ma et al., Scand J Immunol 2011 (Colonic Neoplasms) : This study aims to investigate the role of tumour derived Foxhead box P3 (Foxp3) ( + ) interleukin (IL)-17 ( + ) T cells on suppressing tumour-specific CD8 ( + ) T cells
Castro et al., Cancer Immunol Immunother 2012 (Melanoma, Experimental) : By contrast, Adm5T4 immunized WT mice showed no tumour protection consistent with only low avidity CD8 IFN-?, no IL-17 T cell responses and no detectable CD4 T cell effectors producing IFN-? or IL-17
Gunderson et al., J Invest Dermatol 2013 (Abscess...) : Depletion of CD8 ( + ), but not CD4 ( + ), T cells reduced cutaneous and systemic inflammation, the RAS induced increase in cutaneous Th17 and IL-17 ( + ) ?d T cells, and epidermal hyperproliferation to levels similar to a Rag1-/- background
Shin et al., Cytokine 1998 : Taken together, these results provide evidence that human CD8 ( + ) T cells are also the source of massive expression of IL-17, and that PKA plays a prominent role in the switch of CD8 ( + ) T cells to a Th2 like profile and an inhibition of IL-17 expression, thus suggesting that the activation of cAMP signal transduction pathway may have consequences for the relative role of CD8 ( + ) T cells in the immune and inflammatory process