Bathgate et al., Pharmacol Rev 2006
:
RXFP1 activates adenylate cyclase , protein kinase A, protein kinase C, phosphatidylinositol 3-kinase, and extracellular signaling regulated kinase ( Erk1/2 ) and also interacts with nitric oxide signaling
Halls et al., Br J Pharmacol 2007
:
In contrast, RXFP3 and RXFP4 inhibit adenylate cyclase and RXFP3 causes ERK1/2 phosphorylation