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JUN — PLK3

Text-mined interactions from Literome

Wang et al., J Biol Chem 2007 : Stress induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells ... In the present study, we report that UV irradiation activated Plk3 and that Plk3 interacts with AP-1 and c-Jun, which appears to be important to mediate corneal epithelial cell apoptosis after UV irradiation ... Our results thus provide for the first time that Plk3 mediates UV irradiation induced c-Jun activation by phosphorylating c-Jun, suggesting that Plk3 plays an important role in mediating programmed cell death of corneal epithelial cells after UV irradiation
Wang et al., J Biol Chem 2008 (Anoxia) : The effect of hypoxia/reoxygenation stress induced Plk3 activation on increased c-Jun phosphorylation and apoptosis was also mimicked by exposure of cells to CoCl ( 2 ) ... Our results provide a new mechanism indicating that hypoxia/reoxygenation induces Plk3 activation instead of the JNK effect to directly phosphorylate and activate c-Jun , subsequently contributing to apoptosis in HCE cells
Wang et al., Invest Ophthalmol Vis Sci 2011 : Hyperosmotic stress induced c-Jun phosphorylation was enhanced by overexpression of constitutively positive Plk3 mutants and suppressed by the knockdown of Plk3 mRNA with Plk3-specific siRNA