◀ Back to RELA

GTF2B — RELA

Pathways - manually collected, often from reviews:

• BioCarta the information processing pathway at the ifn beta enhancer: IFN-beta nucleosome complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) → TAFs/TF2A/TBP/TF2F/TF2B/TF2H/TF2E/RNA POL II complex (GTF2A1-NR3C1-GTF2F1-GTF2B-GTF3A-GTF2E1-POLR2A) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) → TAFs/TF2A/TBP/TF2F/TF2B/TF2H/TF2E/RNA POL II complex (GTF2A1-NR3C1-GTF2F1-GTF2B-GTF3A-GTF2E1-POLR2A) (modification, collaborate)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: GTF2B — RELA (direct interaction, pull down) Xia et al., FEBS Lett 2004*
• IRef Biogrid Interaction: GTF2B — RELA (direct interaction, pull down) Schmitz et al., J Biol Chem 1995*
• IRef Hprd Interaction: RELA — GTF2B (in vitro) Xia et al., FEBS Lett 2004*, Schmitz et al., J Biol Chem 1995*
• IRef Intact Interaction: GTF2B — RELA (direct interaction, pull down) Xia et al., FEBS Lett 2004*

Text-mined interactions from Literome

Macián et al., Mol Cell Biol 1999 : Moreover, NFAT1 binds to the kappaB sites on the viral LTR and negatively regulates NF-kappaB mediated activation of HIV-1 transcription , by competing with NF-kappaB1 for its binding sites on the HIV-1 LTR
Takahashi et al., J Virol 2001 : Furthermore, enhanced HIV-1 transcription in gp34 stimulated ACH-2/OX40 cells was dependent on the kappa B site of the HIV-1 long terminal repeat, and the OX40-gp34 interaction activated NF-kappa B consisting of p50 and p65 subunits
Soloff et al., Mol Hum Reprod 2006 : Interleukin-1 induced NF-kappaB recruitment to the oxytocin receptor gene inhibits RNA polymerase II-promoter interactions in cultured human myometrial cells
Klatt et al., J Immunol 2008 : Efficient HIV-1 transcription requires the induction of cellular transcription factors, such as NF-kappaB , and the viral factor Tat, which through the recruitment of P-TEFb enhances processive transcription
Yu et al., Yao Xue Xue Bao 2007 : Among the factors involved in this step, the cellular protein nuclear factor NF-kappaB is the most powerful inducer of HIV-1 transcription ... HIV-1 transcription is initiated by the binding of NF-kappaB to the enhancer region in the long terminal repeat ( LTR ) of HIV-1
Boisvert et al., Virology 2008 : The involvement of NF-kappaB in the PGJ ( 2 ) -dependent down-regulation of HIV-1 transcription was further assessed using the kappaB regulated luciferase encoding vectors
Perkins et al., Mol Cell Biol 1994 : We have previously shown that a cooperative interaction of NF-kappa B with Sp1 is required for the efficient stimulation of HIV-1 transcription
Dumais et al., J Biol Chem 1998 (Second Messenger Systems) : The involvement of NF-kappaB in the PGE2 dependent activating effect on HIV-1 transcription was further confirmed using a kappaB regulated luciferase encoding vector and by electrophoretic mobility shift assays